Douglas A. Bernstein

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  • C E Eldon, B Frederick, David, S Freeman, R Chang, D Varberg +29 others
  • 2007
Objectives: The lectures aim to explain and discuss the knowledge of biology at foundation level which is essential to proceed to higher level of study in biology-related disciplines. On successful completion of this subject, students are expected to be able to: 1. understand the basic features and functions of cells; 2. describe the basic structures and(More)
We generated a high-resolution whole-genome sequence and individually deleted 5100 genes in Sigma1278b, a Saccharomyces cerevisiae strain closely related to reference strain S288c. Similar to the variation between human individuals, Sigma1278b and S288c average 3.2 single-nucleotide polymorphisms per kilobase. A genome-wide comparison of deletion mutant(More)
Antibacterial compounds typically act by directly inhibiting essential bacterial enzyme activities. Although this general mechanism of action has fueled traditional antibiotic discovery efforts for decades, new antibiotic development has not kept pace with the emergence of drug resistant bacterial strains. These limitations have severely restricted the(More)
Cocaine in 6 mg/kg doses was administered orally and intraperitoneally to rats and sleep EEG's recorded. Cocaine significantly reduced total sleep time, slow-wave sleep, and sleep latency. Rapid eye movement sleep (REM) was significantly suppressed during the first half of the sleep recording. These effects were evident by both routes of administration. The(More)
The generation of mature functional RNAs from nascent transcripts requires the precise and coordinated action of numerous RNAs and proteins. One such protein family, the ribonuclease III (RNase III) endonucleases, includes Rnt1, which functions in fungal ribosome and spliceosome biogenesis, and Dicer, which generates the siRNAs of the RNAi pathway. The(More)
  • C E Eldon, B Frederick, David, S Freeman, R Chang, D Varberg +29 others
  • 2007
Objectives: The lectures aim to explain and discuss the knowledge of biology at foundation level which is essential to proceed to higher level of study in biology-related disciplines. On successful completion of this subject, students are expected to be able to: 1. understand the basic features and functions of cells; 2. describe the basic structures and(More)
Early dental experiences were described in essay form by 225 college students reporting either "high" or "low" fear of dentistry. Antecedent factors which appeared to differentiate the two groups most clearly included pain experiences and dentist behaviors. Results were interpreted as supportive of a social-learning model of dental fear acquisition and(More)
Participant modeling, symbolic modeling, and graduated exposure were compared with each other and with two control treatments for effectiveness in reducing fear of dentistry in 33 adults who had avoided dental treatment for from 1 to 10 yr. Assessment of in-chair psychological responsiveness and overt behavior showed no significant pre-post change for any(More)
O ur recent finding that the Candida albicans RNase III enzyme CaDcr1 is an unusual, multifunctional RNase III coupled with data on the RNase III enzymes from other fungal species prompted us to seek a model that explained the evolution of RNase III's in modern budding yeast species. CaDcr1 has both dicer function (generates small RNA molecules from dsRNA(More)
  • M Alex, Ajawani J C, A Arora, R Badaya, K And Bhatnagar, M Asthana +117 others
  • 2012
enhancement programme on college students. (unpublished Ph.D thesis) Aristotle (1984). The complete works of Aristotle: the revised oxford translation (J. Barness, Ed) Princeton: Princeton University press. personality and emotional intelligence with display rule perceptions and emotional labour. Personality and individual difference,s 44, 679-688.(More)