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Gene and cell-based therapies are considered to be potentially powerful new approaches for the management of cystic fibrosis (CF) lung disease. Despite tremendous efforts that have been made, especially in studies to understand the obstacles to gene delivery, major challenges to the application of these approaches remain to be solved. This article will(More)
HIV-1 viral particles engineered to incorporate integrase fused to EGFP (HIV-IN-EGFP) have proven effective to study pre-integration complexes (PICs) within nuclei of infected cells [1]. In this study we now report the live imaging analysis of nuclear PICs obtained by time-lapse microscopy. By monitoring IN-EGFP labeled complex movements within nuclei of(More)
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