Dorothy Silverman

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Rats exposed to 300 ppm para-xylene vapor for 1, 3 or 5 days, 6 h/day, exhibited alterations in pulmonary microsomal membrane structural and metabolic parameters. Following 1 day of exposure, conjugated diene levels were elevated while total phospholipid levels, P-450 content, benzyloxyresorufin O-dealkylase activity and 2-aminofluorene N-hydroxylase(More)
This paper presents the operational concept for onboard processing for the HysIRI mission which is an Earth observing mission that includes both thermal infrared instrument and a hyperspectral visible/shortwave infrared instrument, and that is being considered for launch in the next decade. This article describes the potential application of AI techniques(More)
m-Xylene is a commonly used industrial solvent that has been shown to alter mixed-function oxidase (MFO) activity, in an organ- and isozyme-specific pattern, following intraperitoneal administration of the solvent. The purpose of this work was to determine whether similar alterations occurred in cytochromes P-450 (CYP) following m-xylene inhalation, the(More)
Isomerization of sugars is used in a variety of industrially relevant processes and in glycolysis. Here, we show that hydrophobic zeolite beta with framework tin or titanium Lewis acid centers isomerizes sugars, e.g., glucose, via reaction pathways that are analogous to those of metalloenzymes. Specifically, experimental and theoretical investigations(More)
Toluene (1 g/kg, i.p., 1 and 4 h) was shown to decrease total cytochrome P-450 (P450) content in rat lung. At both timepoints, reduction in pulmonary P450 content was associated with a decrease in aryl hydrocarbon hydroxylase (AHH) activity, a detoxication pathway for benzo[a]pyrene (BaP). At 4 h, toluene increased the toxication/detoxication ratios of BaP(More)
Hyspiri is evaluating a X-band Direct Broadcast (DB) capability that would enable data to be delivered to ground stations virtually as it is acquired. However the HyspIRI VSWIR and TIR instruments will produce 1 Gbps data while the DB capability is 15 M bps for a ~60x oversubscription. In order to address this data volume mismatch a DB concept has been(More)
m-Xylene (1 g/kg, i.p., 1 h) was shown to decrease aryl hydrocarbon hydroxylase (AHH) activity, a detoxification pathway for benzo[a]pyrene (BaP), in the rat lung. Inhibition was maximal at 1 g/kg, 1 h after treatment and was sustained for at least 24 h. Reduction in cytochrome P-450 activity in rat lung was also observed, while liver activity was(More)
The present study investigates the time-dependent effect of acute intraperitoneal o-xylene administration (1 g/kg) on rat hepatic and pulmonary mixed-function oxidase (MFO) content and activity and microsomal membrane structural parameters for up to 12 h postadministration. The purpose of this study was to determine whether o-xylene has similar effects on(More)
The relationship between p-xylene's effects on microsomal membranes, cytochrome P-450, and benzo[a]pyrene (BaP) metabolism was studied. p-Xylene (1 g/kg, ip, 1 h) inhibited 3-hydroxy BaP (3-OH) formation and decreased arylhydrocarbon hydroxylase (AHH) activity approximately 40% in rat lung microsomes. BaP dihydrodiol and quinone formation were unchanged by(More)