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Catalase plays a major role in cellular antioxidant defense by decomposing hydrogen peroxide, thereby preventing the generation of hydroxyl radical by the Fenton reaction. The degree of catalase deficiency in acatalasemic and hypocatalasemic mice varies from tissue to tissue. They therefore may not be suitable for studying the function of this enzyme in(More)
Synthetic human beta-endorphin, 7.25 nmol intracisternally, in unanesthetized, freely moving, chronically cannulated, adult male rats increased plasma concentrations of all 3 catecholamines: epinephrine, norepinephrine and dopamine, for the 2 h period studied. Blockade of these endorphin effects by the prior systemic administration of naloxone supports(More)
To understand the physiological function of glutaredoxin, a thiotransferase catalyzing the reduction of mixed disulfides of protein and glutathione, we generated a line of knockout mice deficient in the cytosolic glutaredoxin 1 (Grx1). To our surprise, mice deficient in Grx1 were not more susceptible to acute oxidative insults in models of heart and lung(More)
EXECUTIVE SUMMARY This report presents the findings of ASHRAE research project RP-821; a field study of occupant comfort and office thermal environments in 12 mechanically ventilated office buildings in southern Quebec. This study is the third of a series of ASHRAE projects (RP-462 and RP-702) which investigated the indoor environment in temperate and(More)
The effect of beta-endorphin on hypothalamic dopamine metabolism was examined in male rats. Intracisternal administration of synthetic human beta-endorphin (15 microgram blunted the alpha-methyltyrosine-induced decline in the concentration of hypothalamic dopamine. Also, beta-endorphin blunted the pargyline-induced accumulation of hypothalamic dopamine.(More)
Catecholamine and serotonin neurons in the hypothalamus regulate the secretion of corticotropin releasing factor (CRF). We considered the possibility that CRF might in turn affect the activity of these aminergic neurons. We examined the effect of intracisternal administration of synthetic CRF on the synthesis turnover rates of dopamine and serotonin in the(More)
The aim of this study was to validate the Chinese version of the Gumpel Readiness Inventory (RI). Participants included 653 preschool children aged three to five years old, their teachers and parents, and 49 children with developmental disabilities. Teachers and parents completed the RI and parents completed the Strength and Difficulty Questionnaire (SDQ)(More)
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