Dorothy Lui

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Active contours are a popular approach for object segmentation that uses an energy minimizing spline to extract an object's boundary. Nonparametric approaches can be computationally complex, whereas parametric approaches can be impacted by parameter sensitivity. A decoupled active contour (DAC) overcomes these problems by decoupling the external and(More)
Prostate cancer is one of the leading causes of cancer death in the male population. The detection of prostate cancer using imaging has been challenging until recently. Multiparametric magnetic resonance imaging (MRI) has been shown to allow accurate localization of the cancers and can help direct biopsies to cancer foci, which is required to plan the(More)
A promising, recently explored, alternative to ultra-high b-value diffusion weighted imaging (UHB-DWI) is apparent ultra-high b-value diffusion-weighted image reconstruction (AUHB-DWR), where a computational model is used to assist in the reconstruction of apparent DW images at ultra-high b -values. Firstly, we present a novel approach to AUHB-DWR that aims(More)
BACKGROUND Prostate cancer is one of the most common forms of cancer found in males making early diagnosis important. Magnetic resonance imaging (MRI) has been useful in visualizing and localizing tumor candidates and with the use of endorectal coils (ERC), the signal-to-noise ratio (SNR) can be improved. The coils introduce intensity inhomogeneities and(More)
Low-dose computed tomography (CT) reduces radiation exposure but decreases signal-to-noise ratio (SNR) and diagnostic capabilities. Noise compensation can improve SNR so low-dose CT can provide valuable information for diagnosis without risking patient radiation exposure. In this study, a novel noise-compensated CT reconstruction method that uses spatially(More)
Fluorescence microscopy is an essential part of a biologist's toolkit, allowing assaying of many parameters like subcellular localization of proteins, changes in cytoskeletal dynamics, protein-protein interactions, and the concentration of specific cellular ions. A fundamental challenge with using fluorescence microscopy is the presence of noise. This study(More)
Rehabilitative Ultrasound Imaging or diagnostic ultrasound is used to measure geometric properties of the lumbar multifidus muscle to infer muscle strength or degeneration for back pain therapy. For this purpose, a novel semi-automatic approach (FTS: Fisher-Tippett Segmentation) based upon the Decoupled Active Contour is proposed to reliably and quickly(More)
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