Dorothy E M Mackerras

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Background: The global rise of Type 2 diabetes and its complications has drawn attention to the burden of non-communicable diseases on populations undergoing epidemiological transition. The life course approach of a birth cohort has the potential to increase our understanding of the development of these chronic diseases. In 1987 we sought to establish an(More)
BACKGROUND In 1987, a prospective study of an Australian Aboriginal Birth Cohort was established focusing on the relationships of fetal and childhood growth with the risk of chronic adult disease. However as the study is being conducted in a highly marginalized population it is also an important resource for cross-sectional descriptive and analytical(More)
A double-blind, placebo-controlled, randomized, factorial study using a daily oral administration of 30 mg beta-carotene and/or 500 mg vitamin C was conducted in 141 women with colposcopically and histologically confirmed minor squamous atypia or cervical intra-epithelial neoplasia (CIN) I. Over approximately 2 years of follow-up, 43 lesions regressed to(More)
OBJECTIVES To describe the prevalence of markers of growth, chronic and infectious disease in peripubertal Aboriginal children living in the Darwin Health Region in the "Top End" of the Northern Territory, and to compare prevalence between children living in urban and remote areas. DESIGN Cross-sectional survey nested in a prospective birth cohort. (More)
The occurrences of positive and negative polarity cloud-to-ground lightning flashes were detected by ground-based lightning flash counters CGR4 in Bris-bane, Australia. Positive (negative) flashes constituted 2–5 per cent (95–98 per cent) of total cloud-to-ground flashes. These results were compared with data obtained by a GPATS lightning location system(More)
OBJECTIVES To determine the effect of adjustment for intraindividual variation on estimations of urinary iodine concentrations (UIC), prevalence of iodine deficiency and population distribution of iodine status. SETTING Community-dwelling older adults from New South Wales, Australia. PARTICIPANTS 84 healthy men and women aged 60-95 years were recruited(More)
OBJECTIVE To illustrate the effect of common mistakes when using 24-hour national dietary survey data to estimate the prevalence of inadequate nutrient intakes. DESIGN Raw data on nutrient intake from the Australian 1995 National Nutrition Survey were adjusted for within-person variance using standard techniques and corrected for underreporting using the(More)
The approach used by food regulation agencies to examine the literature and forecast the impact of possible food regulations has many similar features to the approach used in nutritional epidemiological research. We outline the Risk Analysis Framework described by FAO/WHO, in which there is formal progression from identification of the nutrient or food(More)
ACKNOWLEDGEMENTS This framework paper has been prepared by Dr. Roger Hughes (School of Public Health, Griffith University) with input from members of the Australian Public Health Nutrition Academic Collaboration (APHNAC) and others, listed below. This competency framework is presented in response to the Public Health Education and Research Program (PHERP)(More)
et al. Intraindividual variation in urinary iodine concentrations: effect of adjustment on population distribution using two and three repeated spot urine collections. BMJ Open 2014;4:e003799. ▸ Prepublication history for this paper is available online. To view these files please visit the journal online ABSTRACT Objectives: To determine the effect of(More)