Dorothy E Clyde

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Gradients of regulatory factors are essential for establishing precise patterns of gene expression during development; however, it is not clear how patterning information in multiple gradients is integrated to generate complex body plans. Here we show that opposing gradients of two Drosophila transcriptional repressors, Hunchback (Hb) and Knirps (Kni),(More)
General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights. Take down policy The University of Edinburgh has made every(More)
extramacrochaetae (emc) functions during many developmental processes in Drosophila, such as sensory organ formation, sex determination, wing vein differentiation, regulation of eye photoreceptor differentiation, cell proliferation and development of the Malpighian tubules, trachea and muscles in the embryo. It encodes a Helix-Loop-Helix transcription(More)
Nucleic acid detection with CRISPR-Cas13a/C2c2. Science 356, 438–442 (2017) new tests can be designed and synthesized quickly and cheaply P. M oran/M cm ilan Puishers im ed Point-of-care (POC) diagnostic tools should be sensitive, specific, simple to use, rapid, portable and low cost; however, satisfying all these criteria in a single device without(More)
social behaviours, but the underlying molecular mechanisms are largely unknown. Now, a trio of papers in Cell decribe two genes (orco and corazonin) that control social behaviour in ants. Furthermore, two of the studies describe the first mutant lines in ants, which were generated by CRISPR–Cas9 genome editing. Most social behaviours in ants are mediated by(More)
the outcome of some cancers, but its potential is limited because only a minority of patients respond to treatment. Thus, a major motivation in the field is to identify ‘signatures’ that might predict with high confidence those tumours that can be treated successfully. In this study, Charoentong et al. introduce such a measure for solid tumours — the(More)
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