Dorothy C. Porter

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An unusual alliance called the ARCHway Project is developing an Edition Production Technology (EPT), a technological infrastructure for collaborative research, teaching, and learning between computer scientists and specialists in Old English. Our goal is to identify and solve problems of mutual importance in building image-based electronic editions of(More)
The academic discipline of social medicine has struggled to fi nd a precise definition for over a century. This struggle is exemplified by the classic social medicine course book, The Social Medicine Reader, edited by faculty from the Department of Social Medicine at the University of North Carolina, Chapel Hill, which offers an expansive view of social(More)
Image-based electronic editions enable researchers to view and study in an electronic environment historical manuscript images intricately linked to edition, transcript, glossary and apparatus files. Building image-based electronic editions poses a two-fold challenge. For humanities scholars, it is important to be able to use image and text to successfully(More)
Sea urchin spermatozoa contain a unique histone H1 (SpH1) with an unusual primary structure. Within 12 minutes postinsemination SpH1 is phosphorylated and lost from the chromatin. Both sperm and egg kinases phosphorylate SpH1 in vivo. Until now the analysis of the phosphorylation of SpH1 in eggs in vivo during the first 12 minutes has been impossible(More)
Opaque artifacts containing obscured text continue to present significant challenges to conservators. Often, any attempt to read such fragile texts fundamentally and irreversibly alters the physical structure of the object in which they are contained. Thus, the conservator is presented with an almost impossible dilemma: risk destruction of an artifact in(More)
Two groups of mAbs reacting with external domains of a major sea urchin sperm membrane glycoprotein of 210 kD were isolated. Previous studies have shown that group I mAbs inhibit the acrosome reaction induced by egg jelly and also cause large increases in intracellular Ca2+ [( Ca2+]i). Group II mAbs, at comparable levels of cell surface binding, neither(More)
Phosphorylation of histone H1 occurs when spermatozoa of the sea urchin Strongylocentrotus purpuratus are treated with the macromolecular fraction of solubilized egg jelly. Phosphorylation is on serine residues in the N-terminal fragment of H1 bisected with N-bromosuccinimide. Phosphorylation is maximal by 4-8 min and dependent on Ca2+, but independent of(More)