Dorothy Brown

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Control of cancer, neuropathic, and postoperative pain is frequently inadequate or compromised by debilitating side effects. Inhibition or removal of certain nociceptive neurons, while retaining all other sensory modalities and motor function, would represent a new therapeutic approach to control severe pain. The enriched expression of transient receptor(More)
OBJECTIVE To determine whether the Canine Brief Pain Inventory (CBPI) can detect changes in dogs with osteoarthritis treated with an NSAID or a placebo. DESIGN Double-blind, randomized, placebo-controlled clinical trial. ANIMALS 70 dogs with osteoarthritis. PROCEDURES Owners completed the CBPI on day 0. Dogs received carprofen or a placebo on days 1(More)
OBJECTIVE To develop and psychometrically test an owner self-administered questionnaire designed to assess severity and impact of chronic pain in dogs with osteoarthritis. SAMPLE POPULATION 70 owners of dogs with osteoarthritis and 50 owners of clinically normal dogs. PROCEDURES Standard methods for the stepwise development and testing of instruments(More)
During the 1981 corn harvest season in Illinois and surrounding states, cold wet weather enhanced the growth of Fusarium graminearum, with resulting contamination by vomitoxin and, to a lesser extent, zearalenone. Of 342 feed samples analyzed, 274 contained vomitoxin at a concentration ranging from 0.1 to 41.6 ppm (mean, 3.1 ppm) and 40 samples contained(More)
OBJECTIVE-To determine by use of an accelerometer the sampling interval that has the least variable total activity counts from one week to the next in companion (ie, nonlaboratory) dogs. ANIMALS-80 dogs. PROCEDURES-Dogs wore an accelerometer continuously for 2 weeks. Between-dog and within-dog day-to-day variability in total activity counts were evaluated.(More)
BACKGROUND Lameness assessment using force plate gait analysis (FPGA) and owner assessment of chronic pain using the Canine Brief Pain Inventory (CBPI) are valid and reliable methods of evaluating canine osteoarthritis. There are no studies comparing these 2 outcome measures. OBJECTIVE Evaluate the relationship between CBPI pain severity (PS) and(More)
OBJECTIVE To investigate whether an accelerometer-based activity monitor could be used in pet dogs to differentiate among and delineate the amount of time spent in activities of differing intensity. ANIMALS 104 dogs. PROCEDURES For the first phase of the study, each dog (n = 104) wore an accelerometer-based activity monitor and was led through a series(More)
OBJECTIVE To determine the prevalence of exposure to canine influenza virus (CIV) in dogs in a metropolitan animal shelter. DESIGN Serologic survey. ANIMALS 74 dogs. PROCEDURES Dogs were randomly selected from the canine shelter population. A physical examination was performed, and blood samples were obtained and submitted for serologic testing for(More)
Duplication of the pituitary gland is a rare malformation. The authors describe a patient with features of the median cleft face syndrome (hypertelorism, V-shaped hairline, and developmental delay) who exhibited duplication of the pituitary gland and diffuse thickening of the hypothalamus (hypothalamic hamartoma) as shown by MR. The embryology of the(More)