Dorothee M Aeppli

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CONTEXT Hypertrophic cardiomyopathy (HCM) has been regarded as a disease that causes substantial disability, with annual mortality rates of up to 6%, based largely on reports from tertiary referral centers. OBJECTIVE To assess the clinical course of HCM in a patient cohort more closely resembling the true disease state. DESIGN Retrospective cohort(More)
BACKGROUND Active compression-decompression (ACD) CPR combined with an inspiratory impedance threshold device (ITD) improves vital organ blood flow during cardiac arrest. This study compared survival rates with ACD+ITD CPR versus standard manual CPR (S-CPR). METHODS AND RESULTS A prospective, controlled trial was performed in Mainz, Germany, in which a(More)
BACKGROUND Hypertrophic cardiomyopathy (HCM) has a diverse clinical spectrum that often includes progressive heart failure symptoms and disability. Assessment of symptom severity may be highly subjective, encumbered by the heterogeneous clinical presentation. Plasma B-type natriuretic peptide (BNP) has been used widely as an objective marker for heart(More)
Chronic myelogenous leukaemia (CML) can be cured by donor marrow transplant. Unfortunately, suitably HLA-matched related or unrelated donors are not available for the majority of patients. Transplant of stem cells derived from a patient's own marrow or peripheral blood (autologous transplant) avoids the need for an HLA-matched donor, is associated with a(More)
PURPOSE To determine the potential of proton MR spectroscopy to monitor patients with childhood-onset cerebral adrenoleukodystrophy (COCALD). METHODS Single-voxel MR spectroscopy was performed in 16 children with COCALD (24 examinations) who had had no treatment and in 7 children (13 examinations) who had had bone marrow transplantation. RESULTS In the(More)
In any longitudinal study of periodontitis, it is important to determine when change in probing depth or clinical attachment level occurs as soon as possible. In this study, simulation was used to compare three statistical methods for detecting change in linear periodontal measurement under a variety of conditions including type of change, number of(More)
The G1 cell cycle checkpoint regulates entry into S phase for normal cells. Components of the G1 checkpoint, including retinoblastoma (Rb) protein, cyclin D1 and p16INK4a, are commonly altered in human malignancies, abrogating cell cycle control. Using immunohistochemistry, we examined 79 invasive transitional cell carcinomas of the urinary bladder treated(More)
Brain injury, a leading cause of mortality, morbidity and disability in the United States, has serious consequences and substantial costs. Although previous studies have assessed a variety of outcomes subsequent to brain injury, documentation of performance prior to brain injury using a case-control approach has not been included; preinjury performance(More)
Reliability of clinical measurement is essential to any clinical discipline. This investigation assessed intraexaminer and interexaminer reliability achieved in identifying contacting teeth in the intercuspal position. Shim stock and an articulating film were compared in the evaluation of occlusal contacts of 337 antagonist occlusal pairs in 24 young adults(More)
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