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Twenty-six patients suffering from autosomal dominant cerebellar ataxia type I were subjected to a genotype-phenotype correlation analysis using molecular genetic assignment to the genetic loci for spinocerebellar ataxia type 1, 2 or 3 (SCA1, SCA2, SCA3) and MRI-based volumetry of posterior fossa structures and basal ganglia nuclei. There was significant(More)
This study investigates the time course and regional differences in age-related volume loss in cerebellum and brainstem. Three-dimensional (3D) magnetic resonance imaging (MRI) volumetry was used to measure the volumes of 11 regions in the cerebellum and three regions in the brainstem in 48 healthy volunteers (age 19.8-73.1 years). Landmark-adjusted(More)
A new method was developed to measure total and regional cerebellar volumes using MRI. Previously, the volumes of the cerebellum and its substructure had been studied planimetrically. The new method uses three-dimensional semiautomated volumetry with focus on reliability and performance. The method consists of a manual presegmentation using(More)
This study investigated the influence of slice thickness, section orientation, contrast, shape, and sequence type on the exactness of MRI-based volumetry. Ni-doped agarose gel phantoms (4 to 46 ml) were scanned with a T1-weighted three-dimensional Fourier transform (FT) fast low-angle shot (FLASH) and a multiecho two-dimensional FT-Turbo spin-echo (SE)(More)
We present a system for interactive explorations of extra-and intracranial blood vessels. Starting with a stack of images from 3D angiography, we use virtual clips to limit the segmentation of the vessel tree to the parts the neuroradiologists are interested in. Furthermore, methods of interactive virtual endoscopy are applied in order to provide an(More)
Many of the current environmental problems are caused by the transport of potentially hazardous agricultural and industrial chemicals in soil and aquifers. Most of these chemicals are introduced at the soil-air interface from where they are either directly transported to the underlying aquifer and drainage system or interact with the soil-aquifer matrix and(More)
We present a system for interactive explorations of extra-and intracranial blood vessels. Starting with a stack of images from 3D angiography, we use virtual clips to limit the segmentation of the vessel tree to the parts the neuroradiologists are interested in. Furthermore, methods of interactive virtual endoscopy are applied in order to provide an(More)