Dorota Wiaderna

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The role of the T-type Ca(2+) channel blocker, ethosuximide, the L-type Ca(2+) channel blocker, nimodipine and L-type Ca(2+) channel opener, BAY K8644 (1,4 Dihydro-2, 6-dimethyl-5-nitro-4-[trifluoromethyl)-phenyl]-3-pyridine carboxylic acid methyl ester), was investigated on spike-wave discharges in WAG/Rij rats. This strain is considered as a genetic model(More)
This study was performed to find out whether repeated exposure to toluene might lead to behavioural sensitization estimated on the basis of spontaneous locomotor activity of rats in an open field. As a reference compound amphetamine was used. Toluene at a dose of 740 mg/kg was administered orally, amphetamine at a dose of 1 mg/kg was administered(More)
Pseudocumene (1,2,4-trimethylbenzene, TMB) is a component of several solvent mixtures. During recent studies on rats we investigated the effect of a 4-week (6 h/day, 5 days/week) inhalation exposure to TMB at concentrations of 0, 25, 100, or 250 ppm on radial maze performance, open field activity, passive avoidance, active two-way avoidance, and(More)
Trimethylbenzene (TMB), like xylene (dimethylbenzene), is a significant constituent of some industrial solvent mixtures. In earlier studies, we found that in the rat a subacute low-level inhalation exposure to some of the TMB isomers may result in behavioral alterations detectable weeks after the exposure [Neurotoxicol Teratol 19;1997:327; Int J Occup Med(More)
The relationship between neocortical high voltage spindle activity (HVS) and the level of arousal (state of vigilance) was investigated in imp-DAK rats. Two groups of single records (6 h and 24 h) and one group of repeated ones (6 h daily for three consecutive days) were analysed. Five levels of arousal (states) were distinguished on the basis of(More)
A certain proportion of laboratory rats of various strains show spontaneous nonconvulsive ECoG seizures in the form of bursts of spike-and-wave discharges (SWD). Since in the majority of behavioural experiments the EEG is not controlled, the experimenter is usually unaware of this fact. The purpose of the present work was to find out whether the SWD trait(More)
Trimethylbenzene isomers (TMBs): 1,2,4-TMB (pseudocumene--PS), 1,2,3-TMB (hemimellitene--HM) and 1,3,5-TMB (mesitylene--MES) are important constituents of solvent mixtures. In the US, the adopted TLV-TWA value for TMBs is 125 mg/m3 or 25 ppm (ACGIH 1996). Recent experiments at our laboratory have revealed an impaired learning of passive and active avoidance(More)
It has been hypothesized that exposure to neurotoxins may result in accelerated ageing of the central nervous system (CNS). The present study investigated the effects of a 3-month (6 hr daily, 5 days/week) inhalation exposure of rats to m-xylene, at concentrations of 100 and 1000 ppm, on the spontaneous neocortical spike and wave discharges (SWD) and(More)
Polychlorinated naphthalenes (PCNs), including hexachloronaphthalene (HxCN), are widespread global environmental contaminants. Our experiments were aimed at assessing HxCN effects on motor behavior, long-term memory, pain sensitivity, magnitude of stress-induced analgesia, auditory function and sensorimotor gating, following repeated intragastric(More)
In a series of acute experiments on rats the potential of toluene, mesitylene, hemimellitene and pseudocumene to affect the CNS function was assessed following an analysis of spontaneous and evoked hippocampal and cortical activity. The electrophysiological examinations were performed on rats with recording electrodes chronically implanted into selected(More)