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Male Wistar rats were exposed to pseudocumene vapors at nominal concentration of 25, 100 or 250 ppm in the dynamic inhalation chambers for 6 h or 4 weeks (6 h/day; 5 days/week). Following the inhalation exposure, pseudocumene concentrations were estimated in the brain, liver and lung homogenates, as well as in the brain (brainstem, hippocampus, temporal(More)
Pseudocumene (1,2,4-trimethylbenzene, TMB) is a component of several solvent mixtures. During recent studies on rats we investigated the effect of a 4-week (6 h/day, 5 days/week) inhalation exposure to TMB at concentrations of 0, 25, 100, or 250 ppm on radial maze performance, open field activity, passive avoidance, active two-way avoidance, and(More)
OBJECTIVES Methylmercury (MeHg) and polychlorinated biphenyls (PCBs) are ubiquitous environmental pollutants. Both are neurotoxic, especially for the developing brain. The main source of human exposure to MeHg and PCBs is seafood. The aim of the present work was to find out whether and how separate or combined perinatal exposure to these neurotoxicants(More)
The role of the T-type Ca(2+) channel blocker, ethosuximide, the L-type Ca(2+) channel blocker, nimodipine and L-type Ca(2+) channel opener, BAY K8644 (1,4 Dihydro-2, 6-dimethyl-5-nitro-4-[trifluoromethyl)-phenyl]-3-pyridine carboxylic acid methyl ester), was investigated on spike-wave discharges in WAG/Rij rats. This strain is considered as a genetic model(More)
This study was performed to find out whether repeated exposure to toluene might lead to behavioural sensitization estimated on the basis of spontaneous locomotor activity of rats in an open field. As a reference compound amphetamine was used. Toluene at a dose of 740 mg/kg was administered orally, amphetamine at a dose of 1 mg/kg was administered(More)
Trimethylbenzene (TMB), like xylene (dimethylbenzene), is a significant constituent of some industrial solvent mixtures. In earlier studies, we found that in the rat a subacute low-level inhalation exposure to some of the TMB isomers may result in behavioral alterations detectable weeks after the exposure [Neurotoxicol Teratol 19;1997:327; Int J Occup Med(More)
It has been hypothesized that exposure to neurotoxins may result in accelerated ageing of the central nervous system (CNS). The present study investigated the effects of a 3-month (6 hr daily, 5 days/week) inhalation exposure of rats to m-xylene, at concentrations of 100 and 1000 ppm, on the spontaneous neocortical spike and wave discharges (SWD) and(More)
This study was performed to find out whether in acute exposure to trimethylbenzene (TMB) isomers the dose effect relationship is linear or biphasic. In experiments performed on rats, the effect of four solvents was studied: three TMB isomers: 1,3,5-TMB (mesitylene), 1,2,3-TMB (hemimellitene), and 1,2,4-TMB (pseudocumene), and toluene, known for its biphasic(More)
The purpose of this investigation was to compare the neurotoxic potential of trimethylbenzene (TMB) isomers (the solvents) with that of benzene derivatives with a smaller number of methyl groups (toluene). The experiments were performed on WAG/Rij rats with EEG recording electrodes implanted in the fronto-parietal cortex. The solvents, toluene or TMB(More)
Trimethylbenzene isomers (TMBs): 1,2,4-TMB (pseudocumene--PS), 1,2,3-TMB (hemimellitene--HM) and 1,3,5-TMB (mesitylene--MES) are important constituents of solvent mixtures. In the US, the adopted TLV-TWA value for TMBs is 125 mg/m3 or 25 ppm (ACGIH 1996). Recent experiments at our laboratory have revealed an impaired learning of passive and active avoidance(More)