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The exposure to benzidine under old production conditions, during start-up and at normal work in the new benzidine production division in one of the plants in Poland was compared. In comparison with the old production conditions, in the automatized production process airborne benzidine concentrations were 10-fold lower so that the geometric mean of(More)
Four R mutants of P. mirabilis were isolated. The composition of their degraded polysaccharides (PS) obtained from the respective lipopolysaccharides (LPS) as well as the composition and properties of the PS-fractions separated by column chromatography were examined. The results were compared with those obtained with PS of the wild type. One of the mutants(More)
The present studies concerned 31 work sites in eight factories at which 422 persons were employed. In the course of seven years there were 126 cases of dermatitis, 99 of whom were patch-tested. Positive reactions to epoxy resin and/or to triethylenetetramine were found in 65.7% of the subjects. The aetiology of the other cases is discussed. Some of the(More)
From among 40 workers with dermatitis who did not have contact with phenylglycidyl ether but worked with epoxy resins, 5 were positive to Epidian 5 and phenylglycidyl ether. Cross reactions between these contactants were noted in 3 of the 17 guinea pigs with primary sensitization to epoxy resin or the tested diluent. For 58 persons coming into contact with(More)
A series of N-(aminoalkyl)-4-acetyl-3,5-dimethylpyrrole-2-carboxamides hydrochlorides have been prepared and evaluated as cytostatic agents. General procedures were developed for constructing aminoalkyl chains on the 4-acetylpyrrole-2-carboxylic acid nuclei, utilizing 2-pyridone. The results of the preliminary biological activity have been mentioned.
A seven-stage synthesis of a pyrrole analogue of chloramphenicol (9) is described. The compound exhibits a significant antibacterial activity, over the 3% to 50% range of the chloramphenicol activity: over the 6% to 100% range of the thiamphenicol activity and florfenicol.