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Macrocyclic molecular rotors with bridged steroidal frameworks.
The synthesis and solid-state dynamics of isomeric molecular rotors 7E and 7Z, consisting of two androstane steroidal frameworks linked by the D rings by triple bonds at their C17 positions to a 1,4-phenylene rotator, are described. Expand
Access to 27-Nortomatidine and 27-Norsoladulcidine Derivatives.
The alkaloids were prepared from readily available dinorcholanic lactones via their reaction with 4-chlorobutyllithium followed by substitution of chloride with azide and reductive N-cyclization under the Staudinger conditions. Expand
The synthesis of disteroidal macrocyclic molecular rotors by an RCM approach
Abstract The syntheses of four macrocyclic molecular rotors are described. The starting oxosteroids, 5β-androsterone, and 23-oxosarsasapogenin, were subjected to Grignard ethynylation followed byExpand
Pd-catalyzed steroid reactions
The most important achievements of the last decade in the field of steroid synthesis in the presence of palladium catalysts, exemplified with steroid transformations, are reviewed. Expand
Synthesis, Structure, and Local Molecular Dynamics for Crystalline Rotors Based on Hecogenin/Botogenin Steroidal Frameworks
The synthesis and solid-state characterization of a series of cyclic/acyclic molecular rotors derived from naturally occurring steroidal 12-oxosapogenins are described. The bridged molecular rotorsExpand
Solid State Characterization of Bridged Steroidal Molecular Rotors: Effect of the Rotator Fluorination on Their Crystallization
We describe the synthesis and crystallization of two macrocyclic steroidal compounds labeled (Z)-1F2 and (E)-1F2, envisioned to work as molecular rotors with 1,4-diethynyl-2,3-difluorophenyleneExpand
Revision of the Structure of N, O-Diacetylsolasodine. Unusual Epimerization at the Spiro Carbon Atom during Acetylation of Solasodine.
The steroidal alkaloid solasodine (1) undergoes inversion of configuration at the C-22 spiro atom when treated with acetic anhydride-pyridine at ambient temperature. The basic solvolysis of the N,Expand
New olefin metathesis catalysts bearing polyether clamp in N-heterocyclic carbenes ligands
Abstract Synthesis of new type of the Hoveyda–Grubbs catalysts containing modified N-heterocyclic carbene ligands is described herein. New catalysts bear different in size polyether clamp embracingExpand
Large-Scale Synthesis of a Niche Olefin Metathesis Catalyst Bearing an Unsymmetrical N-Heterocyclic Carbene (NHC) Ligand and its Application in a Green Pharmaceutical Context.
A large-scale synthesis of known Ru olefin metathesis catalyst VII featuring an unsymmetrical N-heterocyclic carbene (NHC) ligand with one 2,5-diisopropylphenyl (DIPP) and one thiophenylmethyleneExpand
Influence of Hydrogen/Fluorine Substitution on Structure, Thermal Phase Transitions, and Internal Molecular Motion of Aromatic Residues in the Crystal Lattice of Steroidal Rotors
Two, acyclic (1) and cyclic (2), steroidal molecular rotors containing 1,4-diethynyl-2,3-difluoro-phenylene units as rotators were investigated by means of single crystal X-ray diffraction, high re...