Dornechia E George

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BACKGROUND Mycosis fungoides (MF), the most common cutaneous T-cell lymphoma, is most often seen in middle-aged to elderly men. OBJECTIVE We conducted a retrospective study of the demographics and prognosis of patients with onset of MF before age 40 years. METHODS Demographic data (age, sex, and race) and histology from 1074 patents with cutaneous(More)
Gastroesophageal reflux (GER) is a common occurrence during infancy. Most children have physiologic reflux that is of little consequence and requires minimal intervention. Pathologic GER, characterized by irritability, apnea, poor weight gain, or respiratory compromise, often requires diagnostic evaluation and aggressive treatment. A framework to help the(More)
Sarcoidosis is a potentially life-threatening, multisystem, granulomatous disease that can present with cutaneous manifestations in patients. A rare cutaneous manifestation of this disease may resemble acquired ichthyosis. We report a 45-year-old woman with a several year history of dyspnea on exertion and panuveitis who presented to a county hospital with(More)
Previously we have shown that rats fed a diet containing raw peanut meal as the sole source of protein exhibited alterations in enzyme activity and composition of certain organs. To determine the effects of isolated peanut lectin on body growth and on the intestines, experiments were carried out in weanling, male, Sprague-Dawley rats fed a casein diet(More)
Various topical and systemic treatments have shown efficacy in plaque and palmoplantar psoriasis; however, studies regarding efficacy in inverse psoriasis are few. The authors present a case of a patient with severe inverse psoriasis who was successfully treated with efalizumab, resulting in complete and sustained remission during prolonged maintenance(More)
Although much of the understanding of the pathogenesis of ulcer disease is derived from data studying adults, there are certain manifestations and presentations that differentiate ulcers in children from those seen in adults. Therapy is aimed at reducing acid or improving mucosal defense. The recent recognition of the association of Helicobacter pylori with(More)
Silver sulfadiazine (SSD) cream, most known for its use in the treatment of extensive burn wounds, is commonly used in the management of erosions in bullous disorders. The beneficial antibacterial effect of SSD use is not without risk, as silver toxicity has been well documented in burn patients. Renal insufficiency accelerates silver accumulation and thus(More)