Doris Winkler

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The effects of nicotine and 1,1-dimethyl-4-phenylpiperazinium (DMPP) on the release of newly synthesized [3H]acetylcholine in mouse cerebral cortical synaptosomes were examined. Nicotine and DMPP produced increases in [3H]acetylcholine release, over the level of spontaneous release, of 24% and 30%, respectively, of a maximum depolarization-induced release(More)
Drug use and problems change dramatically over time in ways that are often described as reflecting an " epidemic cycle ". We use simulation of a model of drug epidemics to investigate how the relative effectiveness of different types of prevention varies over the course of such an epidemic. Specifically we use the so-called LHY model (see Behrens et al.,(More)
In addition to the usual division of the glomerular tuft into lobules, a subdivision into an afferent and an efferent capillary domain is made. Immediately after entering the glomerulus the afferent arteriole splits into superficially located branches which supply the lobules. The capillaries of each lobule first run towards the urinary pole; these parts of(More)
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