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- Michael Kühl, Karin Geis, Laird C. Sheldahl, Tobias Pukrop, Randall T. Moon, Doris Wedlich
- Mechanisms of Development
- 2001
Convergent extension movements are the main driving force of Xenopus gastrulation. A fine-tuned regulation of cadherin-mediated cell-cell adhesion is thought to be required for this process. Members… (More)
- Alexandra Schambony, Doris Wedlich
- Developmental cell
- 2007
XWnt-5A, a member of the nontransforming Wnt-5A class of Wnt ligands, is required for convergent extension movements in Xenopus embryos. XWnt-5A knockdown phenocopies paraxial protocadherin (XPAPC)… (More)
- Jubin Kashef, Almut Koehler, Sei Kuriyama, Dominique Alfandari, Roberto Mayor, Doris Wedlich
- Genes & development
- 2009
Xenopus Cadherin-11 (Xcad-11) is expressed when cranial neural crest cells (CNC) acquire motility. However, its function in stimulating cell migration is poorly understood. Here, we demonstrate that… (More)
- Robert David, Katja Ahrens, Doris Wedlich, Gerhard Schlosser
- Mechanisms of Development
- 2001
We cloned two isoforms of the Xenopus Eya1 orthologue. They show identical patterns of expression that closely resemble the previously described expression of XSix1, but partly differ from the… (More)
- Dietmar Gradl, Michael Kühl, Doris Wedlich
- Molecular and cellular biology
- 1999
beta-Catenin stabilizes the cadherin cell adhesion complex but, as a component of the Wnt/Wg signaling pathway, also controls gene expression by forming a heterodimer with a transcription factor of… (More)
- Annette Borchers, Robert David, Doris Wedlich
- Development
- 2001
Cranial neural crest (CNC) cells migrate extensively, typically in a pattern of cell streams. In Xenopus, these cells express the adhesion molecule Xcadherin-11 (Xcad-11) as they begin to emigrate… (More)
- Christoph Winkler, Christian Eggert, +5 authors Utz Fischer
- Genes & development
- 2005
Spinal muscular atrophy (SMA) is a motoneuron disease caused by reduced levels of survival motoneuron (SMN) protein. Previous studies have assigned SMN to uridine-rich small nuclear ribonucleoprotein… (More)
- André Menke, Claudia Philippi, +4 authors Doris Wedlich
- Cancer research
- 2001
E-cadherin-mediated cell-cell adhesion is reduced in epithelial tumors, which is thought to be a prerequisite to acquire invasive properties. We observed that several pancreatic carcinoma cell lines… (More)
- Tobias Pukrop, Dietmar Gradl, Kristine A. Henningfeld, W Knochel, Doris Wedlich, Michael Kuhl
- The Journal of biological chemistry
- 2001
Some members of the Wnt family of extracellular glycoproteins regulate target gene expression by inducing stabilization and nuclear accumulation of beta-catenin, which functions as a transcriptional… (More)
- Dietmar Gradl, Alexander O. Koenig, Doris Wedlich
- The Journal of biological chemistry
- 2002
Lymphoid enhancer factor/T-cell factor (LEF/TCF) high mobility group box transcription factors are the nuclear transducers of the Wnt/beta-catenin signaling cascade. In Xenopus, three members of the… (More)