Dorine E M Sijpkens

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OBJECTIVE To determine whether the heterogeneous clinical response to tumour necrosis factor (TNF)alpha blocking therapy in rheumatoid arthritis (RA) can be predicted by TNFalpha expression in the synovium before initiation of treatment. METHODS Prior to initiation of infliximab treatment, arthroscopic synovial tissue biopsies were obtained from 143(More)
1 Division of Clinical Immunology and Rheumatology, and 2 Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center/ University of Amsterdam, Amsterdam, the Netherlands. 3 Jan van Breemen Institute, Amsterdam, The Netherlands. 4 Department of Rheumatology, Slotervaart Hospital, Amsterdam, The Netherlands. VU Medical(More)
BACKGROUND The Dutch Law on Medical Services ('Wet Geneeskundige Behandelingsovereenkomst') of 1995 declares that doctors must adhere to an Informed Refusal (a written Refusal of Medical Treatment) if the patient is unable to give informed consent on presentation at hospital. CASE DESCRIPTION A comatose 81-year-old man was presented at the resuscitation(More)
Type I Fc epsilon receptor (Fc epsilon RI) mediated Ca2+ uptake and secretion of rat serosal mast cells have been shown to be inhibited by disodium 1,3-bis [(2'-carboxylatochromon-5'-yl) oxy]-2-hydroxypropane (disodium cromoglycate, DSCG), which is widely employed in the treatment of allergic asthma [Foreman et al. (1977) Br. J. Pharmacol. 59, 473P-474P;(More)
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