Learn More
Monoclonal antibodies (mAbs) are at present one of the fastest growing products of pharmaceutical industry, with widespread applications in biochemistry, biology, and medicine. The operation of mAbs production processes is predominantly based on empirical knowledge, the improvements being achieved by using trial-and-error experiments and precedent(More)
The paper presents the results of mathematical modeling using bond graph methodology applied to cells growing process in pharmaceutical industry. Largely used at industrial scale, the mammalian cell culture represents an important sector with intensive dynamic that requires continuous optimization due to evolution and transformations of medical(More)
A metaheuristic is a general algorithmic framework which can be applied to different optimization problems with relative few modifications to make them adapted to a specific problem. This work describes a dynamic mathematical model for Bacterial growth bioprocess containing 9 unknown parameters, which were calibrated using particle swarm optimization and(More)
1 Návrh robustného decentralizovaného riadenia pomocou LMI In this paper, the robust optimal model matching control design method is applied to a flexible beam Quanser experiment. The neglected nonlinearities of the real experiment in the controller design step lead to important differences between the simulation and experimental results, including(More)
A nonlinear adaptive controller for a class of nonlinear plants with incompletely known and time varying dynamics is presented. It is based on a recurrent neural network used as a dynamical model of the plant. The adaptive controller design is realized by using an input-output feedback linearizing technique. The model parameters, that is the controller(More)
In this paper is presented the real, simulated and virtual experiments for a process station (part of a Flexible Manufacturing System FMS-200) and the benefits of the application of Virtual Reality in education. The used basic concepts of Virtual Reality and description of flexible manufacturing system are provided. The real and simulated experiments of the(More)