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Plasma matrix metalloproteinase and inhibitor profiles in patients with heart failure.
BACKGROUND Changes in myocardial matrix metalloproteinases (MMPs) and the inhibitors of MMPs (TIMPs) have been demonstrated in congestive heart failure (CHF). The first objective of this study was to… Expand
The role of cytokines in disease progression in heart failure.
Recent studies have identified the importance of biologically active molecules such as neurohormones as mediators of disease progression in heart failure. More recently it has become apparent that in… Expand
p53 gene mutation spectrum in human unknown primary tumors.
Mutations affecting the p53 gene are associated with many human malignancies, but little is known about changes in p53 in unknown primary tumors (UPTs), which are characterized as tumors with… Expand
P53 mutations are infrequent and do not correlate with the metastatic potential of human-melanoma cells.
- M. Luca, R. Lenzi, D. Lee-Jackson, M. Gutman, I. Fidler, M. Bar-Eli
- Biology, Medicine
- International journal of oncology
- 1 July 1993
Eleven human melanoma cell lines with different metastatic ability (both spontaneous and experimental) in nude mice, were analyzed for p53 mutations. Mutations in the conserved regions of the p53… Expand
Tumor necrosis factor‐α and the failing human heart–TNFα and heart failure
Tumor necrosis factor‐alpha (TNFα) is a proin‐flammatory cytokine with negative inotropic effects. Recently, elevated levels of TNFα have been identified in patients with advanced heart failure.… Expand
Increased Myocardial Gene Expression of Tumor Necrosis Factor-&agr; and Nitric Oxide Synthase-2: A Potential Mechanism for Depressed Myocardial Function in Hibernating Myocardium in Humans
Background—Whether cardioinhibitory cytokines are elevated in regions of hibernating myocardium and account in part for the depression in resting function is currently not known. Methods and… Expand
Tumor necrosis factor-alpha and the failing human heart.
Tumor necrosis factor-alpha (TNF alpha) is a proinflammatory cytokine with negative inotropic effects. Recently, elevated levels of TNF alpha have been identified in patients with advanced heart… Expand
Tumor necrosis factor-α and failing human heart
Tumor necrosis factor-alpha (TNFα) is a proinflammatory cytokine with negative inotropic effects. Recently, elevated levels of TNFα have been identified in patients with advanced heart failure.… Expand
Tumor necrosis factor alpha and cardiac remodeling
Artifactual frame-shift p53 mutation at codon 249 detected with the Cyclist DNA sequencing method.