Dorcas Alexander

Learn More
This report describes the investigation of mortality of double-crested cormorants (Phalacrocorax auritus), white pelicans (Pelecanus erythrorhynchos), and gulls (Larus spp.) in Alberta, Saskatchewan, and Manitoba during late summer 1990. Techniques used varied among areas, but virological and histopathological examination of birds was done in each area. The(More)
MeIQx and PhIP are putative carcinogenic heterocyclic amines formed during the cooking of meat and fish. Using accelerator mass spectrometry, we have investigated the metabolism and macromolecule binding of 14C-labelled MeIQx and PhIP in human cancer patients compared to the rat. Following oral administration of MeIQx and PhIP, more DNA adducts were formed(More)
1. Introduction In this paper we present our activities towards a Thai Speech-to-Speech translation system. We investigated in the design and implementation of a prototype system. For this purpose we carried out research on bootstrapping a Thai speech recognition system, developing a translation component, and building an initial Thai synthesis system using(More)
Chlorofluorocarbon (CFC) propellants used in metered dose inhalers (MDI) must be replaced under the terms of the Montreal Protocol. Following a review of the available data, HFA134a (1,1,1,2 tetrafluoroethane) was selected as a potential alternative propellant. However, because this data was insufficient to satisfy the stringent requirements for(More)
1. Groups of 60 male and 60 female B6C3F1 mice or HanIbm Wistar rats were exposed to HFA-134a using snout-only inhalation exposure techniques for periods of one hour daily for at least 104 weeks. HFA-134a was delivered directly from cylinders at vapour concentrations of 2500, 15,000 and 75,000ppm for mice and from metered-dose inhalers at vapour(More)
This paper describes the FAME interlingual speech-to-speech translation system for Spanish, Catalan and English, which is intended to assist users in the reservation of a hotel room when calling or visiting abroad. The system has been developed as an extension of the existing NESPOLE! translation system[4] which translates between English, German, Italian(More)
1. HFA-134a was administered to AHA rats by snout-only inhalation for 1 h daily to assess the effects of treatment on reproduction and development. 2. In a fertility study, rats were exposed to atmospheres of 2500, 10,000 or 50,000 p.p.m. HFA-134a throughout gametogenesis, mating, pregnancy and lactation. 3. In a peri- and post-natal study, rats were(More)
Synopsis The manufacturing of toiletries is a complex procedure and many process routes are possible for a given formulation. In the past, considerable attention has been given to the design of manufacturing equipment but there has been relatively little appreciation of the influence of physicochemical interactions during processing. These interactions are(More)
1. This paper reviews the results of preclinical toxicology studies on HFA-134a carried out by Glaxo Research and Development Ltd. 2. A comprehensive range of studies was conducted in animal models suitable for the type of investigation. 3. The inhalation route of administration was used in all in vivo studies (with the exception of local tolerance and(More)