Doo Jin Oh

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The basic characteristics of desensitization of the GABAA receptor were investigated in cultured rat hippocampal neurons (three days to four weeks in vitro) using whole cell patch clamp techniques. GABA at 10-500 microM was perfused on to neurons for 30 or 60 s, with 60 s intervals of wash with control bath solution between perfusions. Desensitization,(More)
The effect of a novel gamma-aminobutyric acid (GABA) uptake inhibitor, NNC-711, on spontaneous postsynaptic currents was studied in cultured rat hippocampal neurons by the whole cell patch clamp method. NNC-711 decreased the amplitude of inhibitory postsynaptic currents (IPSCs) and did not prolong the decay. NNC-711 also decreased the amplitude of(More)
Sir, Cutis vertices gyrata (CVG) is characterized by thickening of the scalp, which becomes raised to form ridges and furrows resembling the cerebral gyri, which cannot be flattened by traction or pressure. The diagnosis is based on clinical features, and further investigations are needed to demonstrate the precise typical features. We describe how(More)
BACKGROUND Combination therapy using cyclosporine A (CsA) together with low-dose corticosteroids has adequate efficacy with little toxicity for the treatment of severe alopecia areata (AA). OBJECTIVE We wanted to evaluate the clinical efficacy of combination therapy using CsA with low-dose corticosteroid for the treatment of severe AA and we also wanted(More)
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