Donna M Wilson

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Previous series that described phenotypes in carriers of Alport's syndrome did not distinguish genetically between carriers of X-linked and autosomal recessive disease. In this study, modes of inheritance in unselected families with Alport's syndrome associated with two city and two provincial hospitals were determined using microsatellite markers, and(More)
OBJECTIVES To measure 1-year post-hip fracture functional recovery, health-related quality of life (HRQL), and mortality in nursing home residents. DESIGN Prospective longitudinal cohort study. SETTING AND PARTICIPANTS Ambulatory nursing home residents with or without impaired cognition consecutively admitted with hip fracture to three Canadian(More)
This 2008 study assessed location-of-death changes in Canada during 1994-2004, after previous research had identified a continuing increase to 1994 in hospital deaths. The most recent (1994-2004) complete population and individual-level Statistics Canada mortality data were analyzed, involving 1,806,318 decedents of all Canadian provinces and territories(More)
Preventing the spread of disease through international trade is one of the primary objectives of the Office International des Epizooties (OIE), the World Organisation for Animal Health. This is accomplished by establishing international standards that facilitate trade while minimising the risk of introducing diseases such as bluetongue (BT). The OIE(More)
BACKGROUND Inherited hematuria is common and is usually attributed to thin basement membrane disease (TBMD). The aim of this study was to determine how often hematuria in families with TBMD segregated with haplotypes at the chromosomal loci for autosomal recessive and X-linked Alport syndrome (COL4A3/COL4A4 and COL4A5, respectively). METHODS The families(More)
AIM The aim of this study was to determine the clinical and laboratory characteristics that distinguished thin basement membrane disease (TBMD) from IgA glomerulonephritis (IgA GN) at presentation and at follow-up. PATIENTS AND METHODS Seventy-one patients with TBMD and 31 with IgA GN were studied. Males accounted for 11/71 (15%) patients with TBMD, and(More)
Unilateral medial meniscectomy was performed on two groups of sheep. At 1 week post-operatively, one group (N = 5) underwent a regimen of moderate walking exercise (24 km/week), while the other group (N = 5) received no exercise. Two groups (N = 6 and 8) of unoperated sheep were used as exercised and unexercised controls for the respective meniscectomized(More)
BACKGROUND Studying where people die across countries can serve as an evidence base for health policy on end-of-life care. This study describes the place of death of people who died from diseases indicative of palliative care need in 14 countries, the association of place of death with cause of death, sociodemographic and healthcare availability(More)
BACKGROUND The place of death is of considerable interest now, yet few studies have determined public preferences for place of end-of-life (EOL) care or final days of life. OBJECTIVE A survey was designed to answer three questions: (1) What are public preferences for the place of last days? (2) Is this place preference related to socio-demographic and(More)
BACKGROUND Pain management is integral to the management of hip fracture. PURPOSE To review the benefits and harms of pharmacologic and nonpharmacologic interventions for managing pain after hip fracture. DATA SOURCES 25 electronic databases (January 1990 to December 2010), gray literature, trial registries, and reference lists, with no language(More)