Donna M . Mancini

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2005 WRITING COMMITTEE MEMBERS Sharon Ann Hunt, MD, FACC, FAHA, Chair; William T. Abraham, MD, FACC, FAHA; Marshall H. Chin, MD, MPH, FACP; Arthur M. Feldman, MD, PhD, FACC, FAHA; Gary S. Francis, MD, FACC, FAHA; Theodore G. Ganiats, MD; Mariell Jessup, MD, FACC, FAHA; Marvin A. Konstam, MD, FACC; Donna M. Mancini, MD; Keith Michl, MD, FACP; John A. Oates,(More)
BACKGROUND The use of left ventricular assist devices is an accepted therapy for patients with refractory heart failure, but current pulsatile volume-displacement devices have limitations (including large pump size and limited long-term mechanical durability) that have reduced widespread adoption of this technology. Continuous-flow pumps are newer types of(More)
Near-infrared (NIR) spectroscopy is a noninvasive technique that uses the differential absorption properties of hemoglobin to evaluate skeletal muscle oxygenation. Oxygenated and deoxygenated hemoglobin absorb light equally at 800 nm, whereas at 760 nm absorption is primarily from deoxygenated hemoglobin. Therefore, monitoring these two wavelengths provides(More)
Mariell Jessup, MD, FACC, FAHA, Chair*; William T. Abraham, MD, FACC, FAHA†; Donald E. Casey, MD, MPH, MBA‡; Arthur M. Feldman, MD, PhD, FACC, FAHA§; Gary S. Francis, MD, FACC, FAHA§; Theodore G. Ganiats, MD ; Marvin A. Konstam, MD, FACC¶; Donna M. Mancini, MD#; Peter S. Rahko, MD, FACC, FAHA†; Marc A. Silver, MD, FACC, FAHA**; Lynne Warner Stevenson, MD,(More)
BACKGROUND Everolimus, a novel proliferation inhibitor and immunosuppressive agent, may suppress cardiac-allograft vasculopathy. We conducted a randomized, double-blind, clinical trial comparing everolimus with azathioprine in recipients of a first heart transplant. METHODS A total of 634 patients were randomly assigned to receive 1.5 mg of everolimus per(More)
OBJECTIVES This study sought to evaluate the use of a continuous-flow rotary left ventricular assist device (LVAD) as a bridge to heart transplantation. BACKGROUND LVAD therapy is an established treatment modality for patients with advanced heart failure. Pulsatile LVADs have limitations in design precluding their use for extended support. Continuous-flow(More)
BACKGROUND Risk stratification of patients with end-stage congestive heart failure is a critical component of the transplant candidate selection process. Accurate identification of individuals most likely to survive without a transplant would facilitate more efficient use of scarce donor organs. METHODS AND RESULTS Multivariable proportional hazards(More)
BACKGROUND Optimal timing of cardiac transplantation in ambulatory patients with severe left ventricular dysfunction is often difficult. To determine whether measurement of peak oxygen consumption (VO2) during maximal exercise testing can be used to identify patients in whom transplantation can be safely deferred, we prospectively performed exercise testing(More)
Gary J. Balady, MD, FAHA, Chair; Ross Arena, PhD, FAHA; Kathy Sietsema, MD; Jonathan Myers, PhD, FAHA; Lola Coke, RN, PhD; Gerald F. Fletcher, MD, FAHA; Daniel Forman, MD; Barry Franklin, PhD, FAHA; Marco Guazzi, MD, PhD; Martha Gulati, MD; Steven J. Keteyian, PhD; Carl J. Lavie, MD; Richard Macko, MD; Donna Mancini, MD; Richard V. Milani, MD, FAHA; on(More)