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Death in ventricular fibrillation was induced consistently in desoxycorticosterone acetate-pretreated rats by the beta-adrenergic agonist isoproterenol but not by norepinephrine or epinephrine, both of which possess alpha- as well as beta-adrenergic activity. Aminophylline, which enhances beta-adrenergic activity, and phenoxybenzamine, an alpha-receptor(More)
In order to determine whether glucocorticoids share the ability of mineralocorticoids in sensitizing the myocardium to the arrhythmogenic property of isoproterenol, albino rats were implanted subcutaneously with prednisone or desoxycorticosterone acetate (DCA). Water was compared with 1% saline as drinking fluid in order to assess the role of a high sodium(More)
In earlier reports from this laboratory, it was shown that 3 weeks' pretreatment with desoxycorticosterone acetate (DCA) pellet implantation and saline as drinking fluid caused a nearly 20,000-fold potentiation of the acute cardiotoxicity of isoproterenol. In such animals, the beta-receptor stimulant consistently elicited severe ventricular dysrhythmias,(More)
The arrhythmogenic activity of four beta-adrenoceptor stimulants, metaproterenol, salbutamol, isoetharine, and dobutamine, was determined in adult, Wistar rats pretreated for 3-4 weeks with desoxycorticosterone (DOCA) and 1% saline as drinking fluid. Doses (SC) of these stimulants which were well tolerated in untreated animals elicited severe ventricular(More)