Donna Lawson

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CONTEXT GH secretion declines rapidly after glucose ingestion and then recovers to higher-than-baseline levels (rebound GH release). HYPOTHESIS Selective metabolic markers predict the magnitude of glucose-suppressed GH release and postglucose rebound-like GH secretion. DESIGN Prospectively randomized crossover study of GH secretion after glucose vs.(More)
CONTEXT Glucose intake is associated with a variable increase in adrenal glucocorticoid secretion. HYPOTHESIS Glucose ingestion elevates cortisol secretion by 1) augmenting pulsatile ACTH release; and/or 2) enhancing ACTH-cortisol synchrony or dose-responsiveness. SUBJECTS Fifty-eight healthy men ages 19-78 yr with computed tomography-estimated(More)
Chronic hyperglycemia inhibits the male gonadal axis. The present analyses test the hypothesis that acute glucose ingestion also suppresses LH and testosterone (T) secretion and blunts the LH-T dose-response function. The design comprised a prospectively randomized crossover comparison of LH and T secretion after glucose vs. water ingestion in a Clinical(More)
By the direct Fick, or the indocyanine-green or both, methods and by renal clearance of inulin and para-aminohippurate (PAH), simultaneous cardiorenal hemodynamic observations were made before and during isoproterenol infusion (0.9-2.6 micrograms/min) into three patients without, and 10 patients with, heart disease. Although a consistent increase in cardiac(More)
OBJECTIVE The purpose of this study was to explore body fat independent effect of second generation antipsychotics (SGAs) on measures of glucose and adipokine homeostasis, and markers of inflammation. METHOD Eight non-diabetic men with schizophrenia (age: 55±3years, BMI: 29.7±1.2kg/m(2)) on SGAs were studied after an overnight fast. DXA and single-cut CT(More)
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