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Six trained middle-distance runners wer studied under alkalotic (NaHCO3 ingestion), placebo (CaCO3 ingestion), and control conditions to determine the effect of an acute induced metabolic alkalosis on time to run an 800-m race. Pre-exercise, following NaHCO3 ingestion, pH and standard [HCO3-] were significantly higher. In the alkalotic condition, subjects(More)
Regular exercise and habitual physical activity are important for patients with cystic fibrosis (CF). Research has demonstrated the benefits of aerobic, anaerobic, and strength exercise training programs for health and quality of life, however, the CF patient is faced with unique barriers and challenges to participation. Recently, increased levels of(More)
Previous studies have reported differences in muscle function and metabolism between patients with cystic fibrosis (CF) and healthy controls (HC), but it is currently unknown whether these abnormalities are specific to CF or also seen in other airway diseases. In this study, we used magnetic resonance spectroscopy (MRS) during exercise to assess muscle(More)
OBJECTIVE The purpose of this study was to determine the fetal response to submaximal maternal exercise at 22 to 26 weeks in pregnancies with abnormal uterine artery Doppler. STUDY DESIGN This was a prospective comparison of singleton pregnancies with uteroplacental vascular insufficiency (UPVI) (mean uterine pulsatility index [PI] values >1.45 [n = 12])(More)
Maximal voluntary ventilation (MVV) may be determined directly by the sprint method or calculated from pulmonary function data, using the functions MVV = forced expired volume in 1 sec (FEV(1)) x 35 or MVV = FEV(1) x 40. The purpose of this paper was to test the validity of the equation over a wide range of lung function in children. Cystic fibrosis (CF), a(More)
We have measured the ventilatory response to inhaled CO2 of six newborn infants in rapid-eye-movement (REM) and non-REM (NREM) sleep. Ventilatory responses were measured using the Read rebreathing technique. The response was further partitioned into the volume contributions of the rib cage and abdominal compartment using the respiratory inductance(More)
The effects of graded induced erythrocythemia on cardiovascular and metabolic responses to intense treadmill running were studied in four highly trained endurance runners. Three autologous infusions of 1 unit (U) whole blood (450 ml/U) were administered sequentially 2-7 days apart. Maximal O2 consumption (VO2max) increased from 5.04 l/min at control (C) to(More)
Our objective was to study exercise capacity and cardiorespiratory response to exertion in survivors of congenital diaphragmatic hernia (CDH). This was a cross-sectional cohort study of 23 CDH survivors, aged 10-16 years, and 23 gender- and age-matched controls. Exercise testing was performed on a cycle ergometer, with cardiac output measurements made using(More)
The effect of facial attachments on breathing was measured by respiratory induction plethysmography (RIP) during quiet sleep in 32 studies in 18 infants. The addition of a face mask plus pneumotachograph led to an increase in tidal volume (VT) (22.0 +/- 13.5%, p less than 0.01) during 5-min sleep studies when compared to measurements using RIP alone.(More)
Exercise is beneficial for patients with cystic fibrosis (CF) but long-term effects of physical activity on lung function evolution are unknown. We evaluated the longitudinal relationship between changes in habitual physical activity (HPA) and rate of decline in lung function in patients with CF. We tracked HPA using the Habitual Activity Estimation Scale,(More)