Donna L Reynolds

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BACKGROUND Prenatal screening and the promotion of folic acid intake could affect the incidence of neural tube defects (NTDs). We examined trends in the total NTD incidence, as detected in live births, stillbirths and therapeutic abortions, from 1986 to 1999 in Ontario. METHODS To capture cases of NTDs we used data from the Canadian Congenital Anomalies(More)
BACKGROUND AND PURPOSE The effects of dofetilide were studied in monkeys and dogs. Pharmacokinetic data were generated together with the monitoring of cardiovascular changes in order to compare effects relative to human exposure. EXPERIMENTAL APPROACH Beagle dogs and cynomolgus monkeys were telemetered to collect arterial blood pressure, heart rate and(More)
The dose proportionality of deflazacort was assessed following single-dose oral administration at doses of 3, 6, and 36 mg to 24 healthy young adult volunteers. The active metabolite of deflazacort (21-desacetyl deflazacort) was monitored in plasma using a sensitive, semi-microbore liquid chromatographic method. Cmax averaged 10.4 +/- 5.0, 19.8 +/- 7.5, and(More)
OBJECTIVES To describe the immunogenicity and safety of a two-dose series of a quadrivalent meningococcal (serogroups A, C, Y and W) polysaccharide diphtheria toxoid conjugate vaccine (MenACYW-D) administered to toddlers. METHODS Children were randomly assigned (1:1) at study entry to receive MenACYW-D at 12 and 18 months of age (group 1; n=61) or(More)
Berrington et al. published data purporting to show that immunisation of pre-term infants with concomitant IPV could reduce the anti-PRP response to Haemophilus influenzae type b vaccine [1]. Furthermore, they concluded that this may have some relevance to the combination infant vaccine routinely used in the UK (Pediacel®: DT5aP-IPV-Hib, Sanofi Pasteur(More)
The safety, pharmacokinetics, and pharmacodynamics of single oral doses of up to 48 mg and daily (for 28 days) doses of up 24 mg mofegiline were investigated in healthy male volunteers. Plasma pharmacokinetics indicated rapid absorption and elimination: time to reach maximum concentration occurred at about 1 hour; half-life ranged from 1 to 3 hours. Maximal(More)
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