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Non-primate mammalian activity cycles are highly variable across and within taxonomic groups. In contrast, the order Primates has historically been recognized as displaying a diurnal-nocturnal dichotomy that mapped, for the most part, onto the taxonomic division between haplorhines and strepsirhines. However, it has become clear over the past two decades(More)
BACKGROUND Limited data are available describing the clinical presentation and risk factors for admission to the intensive care unit for children with 2009 H1N1 infection. METHODS We conducted a retrospective chart review of all hospitalized children with 2009 influenza A (H1N1) and 2008-09 seasonal influenza at The Children's Hospital, Denver, Colorado.(More)
OBJECTIVE To analyze the spectrum of neurological manifestations in children hospitalized with pandemic influenza A H1N1 virus of 2009 (pH1N1). DESIGN Retrospective case series of children hospitalized from May 1, 2009, through November 30, 2009. SETTING Tertiary-care children's hospital in Colorado. PATIENTS All hospitalized patients with pH1N1 with(More)
OBJECTIVES We investigated immune determinants of antibody responses and B-cell memory to pH1N1 vaccine in HIV-infected children. METHODS Ninety subjects 4 to <25 years of age received two double doses of pH1N1 vaccine. Serum and cells were frozen at baseline, after each vaccination, and at 28 weeks post-immunization. Hemagglutination inhibition (HAI)(More)
The live-attenuated influenza vaccine (LAIV) has generally been more efficacious than the inactivated vaccine in children. However, LAIV is not recommended for HIV-infected children because of insufficient data. We compared cellular, humoral, and mucosal immune responses to the 2013-2014 LAIV quadrivalent (LAIV4) in HIV-infected and uninfected children 2-25(More)
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