• Publications
  • Influence
Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress
TLDR
It is proposed that Keap1 is a component of a novel E3 ubiquitin ligase complex that is specifically targeted for inhibition by both chemopreventive agents and oxidative stress. Expand
Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival
TLDR
The data demonstrate that Nrf2 is a critical effector of PERK-mediated cell survival, and it is demonstrated that cells harboring a targeted deletion of NRF2 exhibit increased cell death relative to wild-type counterparts following exposure to ER stress. Expand
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
TLDR
The mechanisms underlying ferroptosis are reviewed, connections to other areas of biology and medicine are highlighted, and tools and guidelines for studying this emerging form of regulated cell death are recommended. Expand
Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex
TLDR
The results suggest that the ability of Keap1 to assemble into a functional E3 ubiquitin ligase complex is the critical determinant that controls steady-state levels of Nrf2 in response to cancer-preventive compounds and oxidative stress. Expand
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
The emerging role of the Nrf2-Keap1 signaling pathway in cancer.
TLDR
The studies suggest that Nrf2 contributes to both intrinsic and acquired chemoresistance, and the challenges in the development of NRF2-based drugs for chemoprevention and chemotherapy are outlined. Expand
Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway
TLDR
Recent progress in the field of the Nrf2-Keap1 signaling pathway is discussed, with emphasis on the mechanistic studies of NRF2 regulation by Keap1, oxidative stress, or chemopreventive compounds. Expand
A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62
TLDR
It is shown that autophagy deficiency activates the Nrf2 pathway in a noncanonical cysteine-independent mechanism, and this findings demonstrate that p62-mediated NRF2 upregulation is Keap1 dependent. Expand
Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response.
TLDR
Molecular and genetic evidence is presented suggesting that the antioxidant function of p21 is mediated through activation of NRF2 by stabilizing the Nrf2 protein, and the physiological significance of the findings was demonstrated in vivo using p21-deficient mice. Expand
Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response
TLDR
It is reported that p300/CBP directly acetylates Nrf2 in response to arsenite-induced stress and established acetylation as a novel regulatory mechanism that functions in concert with Keap1-mediated ubiquitination in modulating the NRF2-dependent antioxidant response. Expand
...
1
2
3
4
5
...