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Molecular Determinants and the Regulation of Human Cytomegalovirus Latency and Reactivation
Human cytomegalovirus (HCMV) is a beta herpesvirus that establishes a life-long persistence in the host, like all herpesviruses, by way of a latent infection. During latency, viral genomes areExpand
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Alternative Promoters Drive Human Cytomegalovirus Reactivation from Latency
Reactivation from latency requires reinitiation of viral gene expression and culminates in the production of infectious progeny. The major immediate early promoter (MIEP) of human cytomegalovirusExpand
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HCMV Reprogramming of Infected Monocyte Survival and Differentiation: A Goldilocks Phenomenon
The wide range of disease pathologies seen in multiple organ sites associated with human cytomegalovirus (HCMV) infection results from the systemic hematogenous dissemination of the virus, which isExpand
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Human Cytomegalovirus Utilizes a Nontraditional Signal Transducer and Activator of Transcription 1 Activation Cascade via Signaling through Epidermal Growth Factor Receptor and Integrins To
ABSTRACT Human cytomegalovirus (HCMV) infects peripheral blood monocytes and triggers biological changes that promote viral dissemination and persistence. We have shown that HCMV induces aExpand
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Viral binding-induced signaling drives a unique and extended intracellular trafficking pattern during infection of primary monocytes
Significance Human cytomegalovirus (HCMV)-infected monocytes play a critical role in the hematogenous dissemination of the virus, establishment of persistence, and progression of HCMV-mediatedExpand
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A quantitative evaluation of cell migration by the phagokinetic track motility assay.
Cellular motility is an important biological process for both unicellular and multicellular organisms. It is essential for movement of unicellular organisms towards a source of nutrients or away fromExpand
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The Loss of Binary: Pushing the Herpesvirus Latency Paradigm
Purpose of ReviewHerpesvirus latency has been viewed as a binary state where replication is either on or off. During latency, gene expression is thought to be restricted to non-coding RNAs or veryExpand
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HCMV Infection and Apoptosis: How Do Monocytes Survive HCMV Infection?
Human cytomegalovirus (HCMV) infection of peripheral blood monocytes plays a key role in the hematogenous dissemination of the virus to multiple organ systems following primary infection orExpand
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Alternative promoters drive human cytomegalovirus reactivation from latency
Significance Cytomegalovirus is a herpesvirus that persists latently for the host’s lifetime, with periodic reactivation that can cause life threatening disease in individuals with inadequateExpand
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FOXO Transcription Factors Activate Alternative Major Immediate Early Promoters to Induce Human Cytomegalovirus Reactivation
A key step during viral reactivation from latency is the re-expression of viral genes. Hematopoietic progenitor cells (HPCs) support human cytomegalovirus (HCMV) latency, and their differentiationExpand
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