• Publications
  • Influence
Monanchosterols A and B, bioactive bicyclo[4.3.1]steroids from a Korean sponge Monanchora sp.
Chemical investigation of a Korean marine sponge, Monanchora sp., led to the isolation of three new steroids (1-3). Compounds 1 and 2, designated as monanchosterols A and B, respectively, representExpand
Sterols from a soft coral, Dendronephthya gigantea as farnesoid X-activated receptor antagonists
Three new steroids 3-oxocholest-1,22-dien-12β-ol, 1 and 2 showed notable inhibitory activity against farnesoid X-activated receptor (FXR) with IC(50)'s 14 and 15μM. Expand
Phosphoiodyns A and B, unique phosphorus-containing iodinated polyacetylenes from a Korean sponge Placospongia sp.
Two unprecedented phosphorus-containing iodinated polyacetylenes, phosphoiodyns A and B, were isolated from a Korean marine sponge and exhibited potent agonistic activity on human peroxisome proliferator-activated receptor delta. Expand
Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis
A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1Expand
Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment
Antartin (1), a new zizaane-type sesquiterpene, showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase. Expand
Bioconverted Orostachys japonicas Extracts Suppress Angiogenic Activity of Ms-1 Endothelial Cells
  • S. Lee, J. Kim, +5 authors Ju-Ock Nam
  • Chemistry, Medicine
  • International journal of molecular sciences
  • 1 December 2017
BOE, but not OE, were found to exert anti-angiogenic effects, including inhibition of cell migration, cell adhesion, tube formation of Ms-1 cells, and blood vessel formation of matrigel plug assay in vivo. Expand
A stereo-controlled synthesis of 2,4-dimethyl-4-hydroxy-16-phenylhexadecanoic acid 1,4-lactone and its PPAR activities.
A novel class of natural PPAR agonists, 2, 4-dimethyl-4-hydroxy-16-phenylhexadecanoic acid 1,4-lactone, were discovered in marine natural product libraries and achieved ring formation of the α,γ dialkyl γ- lactone via the stereo-controlled reaction of a ketyl radical anion with a chiral methacrylate. Expand
Thiol Probes To Detect Electrophilic Natural Products Based on Their Mechanism of Action.
A reactivity-guided drug discovery approach for electrophilic natural products, a therapeutically relevant class of natural products that covalently modify their cellular targets, in crude extracts using carefully designed halogenated aromatic reagents. Expand
Phorbaketals L-N, cytotoxic sesterterpenoids isolated from the marine sponge of the genus Phorbas.
Three new sesterterpenoids, phorbaketals L-N (1-3), were isolated from a marine sponge of the genus Phorbas and their complete structures were elucidated via analysis of HRFABMS and NMR spectroscopicExpand
Phorone A and isophorbasone A, sesterterpenoids isolated from the marine sponge Phorbas sp.
A chemical investigation of a Korean marine sponge yielded unprecedented sesterterpenoids phorone A and isophor Basone A along with ansellone B and phorbasone A acetate, which have the new "phorane"(5) and "isophorbasane"(6) sestersterpenoid carbon skeletons, respectively. Expand