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Genetically modified adenoviral vector with the protein transduction domain of Tat improves gene transfer to CAR-deficient cells
TLDR
PTD.AdeGFP significantly improved gene transfer to multiple cell types deficient in expression of CAR and was able to transduce target cells in a dynamin-independent pathway, which would be valuable in gene-function analysis and for gene therapy in cancer.
Adenoviral delivered eGFP-intron splicing system for multiple gene RNAi
TLDR
This is the first report of multi-siRNA engineering technology in the context of adenoviral vector which would enable concomitant knockdown of tumor-related target genes.
Aptamer modification improves the adenoviral transduction of malignant glioma cells.
Disease and Region Specificity of Granulin Immunopositivities in Alzheimer Disease and Frontotemporal Lobar Degeneration
TLDR
Evaluated PGRN/Grn in brains of patients with Alzheimer disease, FTLD-TDP type A with or without GRN mutations, and normal individuals, using a panel of monoclonal antibodies against Grn peptides A-G found disease-specific changes in both neurons and microglia.
A fiber chimeric CRAd vector Ad5/11-D24 double-armed with TRAIL and arresten for enhanced glioblastoma therapy.
TLDR
The results indicated that the CRAd5/11-D24.TRAIL/arresten achieved nearly complete inhibition of glioma growth in nude mice possibly by increased antiangiogenesis and enhanced tumor apoptosis.
Detection of CD133 expression in U87 glioblastoma cells using a novel anti-CD133 monoclonal antibody.
TLDR
One of the antibodies produced against CD133 ectodomain 2, C2E1, detected high expression levels of CD133 protein in glioblastoma U87 cells, in contrast to previous studies which did not detect CD133 expression in these cells.
A Highly Sensitive Sandwich ELISA to Detect CSF Progranulin: A Potential Biomarker for CNS Disorders.
TLDR
Results indicate that this ELISA system can be valuable in studying the diagnostic and prognostic value of CSF PGRN in brain disorders and could monitor CNS metastasis and CSF seeding of carcinomas.
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