Dongxiao Ding

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The cause of the induced CD bands of DNA-Hg2+ and DNA-Ag+ complexes has been interpreted as a condensed psi state (Walter, A. and Luck, G. (1977) Nucl. Acids Res. 4, 539-550). Electric dichroism and sedimentation velocity experiments indicate that there is no tertiary structure formation of DNA-heavy-metal-ion complexes to support a psi state. The increase(More)
CD studies of known sequence DNA-like polynucleotide-Hg2+ complexes have established a cross-strand binding of Hg2+ to the two thymines of the base-paired first-neighbor unit TpA, as the type I binding mode of poly[d(A-T) x d(A-T)] and other polynucleotides with high TpA incidence. The amino group of adenine is the most probable Hg2+ site for poly(A) and(More)
An air-conditioned coach is an important form of transportation in modern motorized society; as a result, there is an increasing concern of in-vehicle air pollution. In this study, we aimed to identify and quantify the levels of volatile organic compounds (VOCs) and carbonyl compounds (CCs) in air samples collected from the cabins of newly produced, medium-(More)
Exposure to Bisphenol A (BPA) has been associated with the development of nonalcoholic fatty liver disease (NAFLD) but the underlying mechanism remains unclear. Given that microRNA (miRNA) is recognized as a key regulator of lipid metabolism and a potential mediator of environmental cues, this study was designed to explore whether exposure to BPA-triggered(More)
Bisphenol A (BPA) can disrupt glucose homeostasis and impair pancreatic islet function; however, the mechanisms behind these effects are poorly understood. Male mice (4 wk old) were treated with BPA (50 or 500 μg/kg/day) for 8 wk. Whole-body glucose homeostasis, pancreatic islet morphology and function, and miR-338-mediated molecular signal transduction(More)
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