The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway
- Peter M Sullivan, Xiaolai Zhou, Fenghua Hu
- Biology, ChemistryActa Neuropathologica Communications
- 18 May 2016
This study elucidates potential physiological functions of C9orf72 and disease mechanisms of ALS/FTLD and demonstrates that C 9orf72/SMCR8/WDR41 associates with the FIP200/Ulk1 complex, which is essential for autophagy initiation.
Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition
This study uncovers a flexible non-uniform fitness mechanism that enables groups of cells within a population to rapidly bypass the effect of treatment and must be overcome if complete and durable responses in the clinic.
Phylogeography of an intertidal direct-developing gastropod Batillaria cumingi around the Japanese Islands
- S. Kojima, I. Hayashi, Dongsung Kim, A. Iijima, T. Furota
- Environmental Science, Biology
- 2 August 2004
The phylogeography of the direct-developing intertidal gastropod Batillaria cumingi was examined by comparing the nucleotide sequences of part of the mitochondrial gene for cytochrome c oxidase…
Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step
A computational model of glycolysis and an integrated analysis using metabolic control analysis (MCA), metabolomics data, and statistical simulations identified and confirmed a novel mode of regulation specific to aerobic glyCOlysis where flux through GAPDH is the rate-limiting step in the pathway and the levels of fructose (1,6) bisphosphate (FBP), are predictive of the rate and control points in gly colysis.
Targeting KRAS(G12C): From Inhibitory Mechanism to Modulation of Antitumor Effects in Patients
Phosphoproteomics reveals distinct modes of Mec1/ATR signaling during DNA replication.
An exploration of Echinoderes (Kinorhyncha: Cyclorhagida) in Korean and neighboring waters, with the description of four new species and a redescription of E. tchefouensis Lou, 1934
A large collection of kinorhynch specimens from coastal and subtidal localities around the Korean Peninsula and in the East China Sea was examined, and the material included several species of…
Submersible Observations of the Hydrothermal Vent Communities on the Iheya Ridge, Mid Okinawa Trough, Japan
During the Dives Nos. 409, 410, 480 and 481 of the Japanese submersible Shinkai 2000, conducted on June 10 and 11, 1989 and on May 16 and 17, 1990, several hydrothermal vents and prosperous vent…
A New Species of Condyloderes (Cyclorhagida, Kinorhyncha) from Korea
A new kinorhynch species, Condyloderes megastigma sp. nov., is described from the Korea Strait. The new species is characterized by the presence of 16 placids with either eight, four, or two knobby…
Progranulin deficiency leads to reduced glucocerebrosidase activity
It is reported that PGRN interacts with the lysosomal enzyme, glucocerebrosidase (GBA), and is essential for proper GBA activity, and is significantly reduced in tissue lysates from PGRn-deficient mice, further evidence that reduced lysOSomal hydrolase activity may be a pathological mechanism in cases of GRN-related FTLD and NCL.