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Hexanucleotide repeat expansion in the C9orf72 gene is a leading cause of frontotemporal lobar degeneration (FTLD) with amyotrophic lateral sclerosis (ALS). Reduced expression of C9orf72 has been proposed as a possible disease mechanism. However, the cellular function of C9orf72 remains to be characterized. Here we report the identification of two binding(More)
The use of virtualization is rapidly expanding from server consolidation to various computing systems including PC, multimedia set-top box and gaming console. However, different from the server environment , timeliness response for the external input is an essential property for the user-interactive applications. To provide timeliness scheduling of virtual(More)
In this paper, we propose a fully automatic method for vertebra segmentation in the CT volume data. The method constructs 3D fences that separate adjacent vertebrae from valley-emphasized Gaussian images. Initial curves for the 3D fences are extracted from intervertebral discs, detected with anatomical characteristics, then optimized using a deformable(More)
The Mec1/Tel1 kinases (human ATR/ATM) play numerous roles in the DNA replication stress response. Despite the multi-functionality of these kinases, studies of their in vivo action have mostly relied on a few well-established substrates. Here we employed a combined genetic-phosphoproteomic approach to monitor Mec1/Tel1 signaling in a systematic, unbiased,(More)
We introduce an efficient method for recognition and localization of generic objects for robot navigation, which works on real scenes. The generic objects used in our experiments are desks and doors as they are suitable landmarks for navigation. The recognition method uses significant surfaces and accompanying functional evidence for recognition of such(More)
This paper describes the design and implementation of a home network system using UPnP middleware and an embedded interface device. The developed home network system comprises a home server program, appliance emulators; (e.g., for l'K refrigerator, and air-conditioner), and an embedded interface device for networked home appliances.
Fluxes are the central trait of metabolism and Kinetic Flux Profiling (KFP) is an effective method of measuring them. To generalize its applicability, we present an extension of the method that estimates the relative changes of fluxes using only relative quantitation of 13C-labeled metabolites. Such features are directly tailored to the more common(More)