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Effect of Mas‐related gene (Mrg) receptors on hyperalgesia in rats with CFA‐induced inflammation via direct and indirect mechanisms
TLDR
The effects of MrgC receptor activation on inflammatory hyperalgesia and its mechanisms are investigated in trigeminal and dorsal root ganglia of DRG. Expand
Hesperidin Alleviates Cognitive Impairment, Mitochondrial Dysfunction and Oxidative Stress in a Mouse Model of Alzheimer’s Disease
TLDR
Findings suggest that a reduction in mitochondrial dysfunction through the inhibition of GSK-3β activity, coupled with an increase in anti-oxidative defense, may be one of the mechanisms by which hesperidin improves cognitive function in the APPswe/PS1dE9 transgenic mouse model of AD. Expand
Naringin Improves Neuronal Insulin Signaling, Brain Mitochondrial Function, and Cognitive Function in High-Fat Diet-Induced Obese Mice
TLDR
Findings suggest that an enhancement in insulin signaling and a decrease in mitochondrial dysfunction through the activation of AMPK may be one of the mechanisms that naringin improves cognitive functions in HFD-induced obese mice. Expand
Loss of astrocytic glutamate transporters in Wernicke encephalopathy
TLDR
The results suggest that loss of EAAT1 and EAAT2 glutamate transporters is associated with structural damage to the frontal cortex in patients with THE AUTHORS, oxidative stress plays an important role in this process, and TD has a profound effect on the functional integrity of astrocytes. Expand
Topical and systemic administrations of ketanserin attenuate hypersensitivity and expression of CGRP in rats with spinal nerve ligation.
TLDR
Results support the hypothesis that adaptive change in CGRP expression that occurred in theDRG adjacent to the DRG containing injured neurons underlies the nerve ligation-induced hypersensitivity and suggest topical and systemic administrations of ketanserin are promising therapies for relieving neuropathic pain without tolerance. Expand
Activated microglia in the spinal cord underlies diabetic neuropathic pain.
TLDR
The present review highlights the recent developments regarding the contribution of spinal microglia as compelling target for the treatment of DNP and elucidate glial mechanisms underlying DNP for the development of effective therapeutic agents. Expand
Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha.
TLDR
It is reported that basal Rgmc levels in Hfe-deficient mice are normal and that these mice retain the ability to suppress RgMC expression after lipopolysaccharide (LPS) challenge, and that tumor necrosis factor-alpha, but not interleukin-6, is sufficient to cause RgMc down-regulation by LPS. Expand
A Role for Protein Kinase C-Dependent Upregulation of Adrenomedullin in the Development of Morphine Tolerance in Male Rats
TLDR
Results reveal that a sustained opiate treatment induces an upregulation of AM through the activation of μ-opioid receptors and the PKC signaling pathway, which contributes to the development of tolerance to the antinociceptive effects of opiates at least partially via the up regulation of CGRP. Expand
The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases
TLDR
Three upstream pathways of mTOR are summarized and their role in liver fibrosis, hepatitis B, non-alcoholic fatty liver, liver cancer, hepatic ischemia reperfusion and other liver diseases through the regulation of m TOR-mediated autophagy is explored. Expand
Blockade of adrenomedullin receptors reverses morphine tolerance and its neurochemical mechanisms
TLDR
The results suggest that the activation of AM receptors was involved in the maintenance of morphine tolerance mediating by not only upregulation of the pronociceptive mediators, nNOS and CGRP but also the down-regulation of pain-inhibiting molecule BAM22. Expand
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