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Poly (Lactide-co-Glycolide) Microspheres in Respirable Sizes Enhance an In Vitro T Cell Response to Recombinant Mycobacterium tuberculosis Antigen 85B
PurposeTo investigate the use of poly (lactide-co-glycolide) (PLGA) microparticles in respirable sizes as carriers for Antigen 85B (Ag85B), a secreted protein of Mycobacterium tuberculosis, with theExpand
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Screening for Potential Adjuvants Administered by the Pulmonary Route for Tuberculosis Vaccines
Tuberculosis (TB) infects one third of the world’s population, and new infections occur at a rate of 1/s. Better vaccines are needed than the live mycobacterium Bacille Calmette-Guérin (BCG).Expand
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International Guidelines for Bioequivalence of Locally Acting Orally Inhaled Drug Products: Similarities and Differences
International regulatory agencies have developed recommendations and guidances for bioequivalence approaches of orally inhaled drug products (OIDPs) for local action. The objective of this article isExpand
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Pulmonary Immunization Using Antigen 85-B Polymeric Microparticles to Boost Tuberculosis Immunity
This study aims to evaluate immunization with polymeric microparticles containing recombinant antigen 85B (rAg85B) delivered directly to the lungs to protect against tuberculosis. rAg85B wasExpand
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Genetic Stability, Active Constituent, and Pharmacoactivity of Salvia miltiorrhiza Hairy Roots and Wild Plant
Salvia miltiorrhiza is an annual plant growing in China, Mongolia, Korea and some other Asian countries. The extract from S. miltiorrhiza roots has been used for supporting healthy cardiovascular andExpand
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Profiling of lung microbiota in the patients with obstructive sleep apnea
Abstract Lung microbiota may affect innate immunity and treatment consequence in the obstructive sleep apnea (OSA) patients. Bronchoalveolar lavage fluid (BALF) was obtained from 11 OSA patients andExpand
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Potential inflammatory markers in obstructive sleep apnea-hypopnea syndrome.
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a complex chronic inflammatory respiratory disease with multiple pathogenic factors and high morbidity and mortality. Serum levels of nuclearExpand
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Salmeterol combined with fluticasone propionate improved COPD in patients during stable stage.
PURPOSE To evaluate the clinical effect of inhaled Salmeterol with Fluticasone propionate (50:500 μg) in patients with moderate to severe chronic obstructive pulmonary disease (COPD) during theExpand
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Frequency of sleep-disordered breathing in a referral population of Somali-Americans.
STUDY OBJECTIVE To study the frequency of OSA in individuals of Somali ancestry referred to a clinical sleep laboratory. METHODS Retrospective study using a large registry of patients who underwentExpand
Common Deficiencies of in vitro Binding Bioequivalence (BE) Studies Submitted in Abbreviated New Drug Applications (ANDAs)
There are several drug products that bind phosphate or bile acid in the gastrointestinal (GI) tract to exert their therapeutic efficacy. In vitro binding studies are used to assess bioequivalenceExpand