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Highly-optimized placements may lead to irreparable routing congestion due to inadequate models of modern interconnect stacks and the impact of partial routing obstacles. Additional challenges in routability-driven placement include scalability to large netlists and limiting the complexity of software integration. Addressing these challenges, we develop(More)
Homogeneous culture of neural precursor cells (NPCs) derived from human pluripotent stem cells (hPSCs) would provide a powerful tool for biomedical applications. However, previous efforts to expand mechanically dissected neural rosettes for cultivation of NPCs remain concerns regarding non-neural cell contamination. In addition, several attempts to purify(More)
Traditional IC design flows optimize clock networks before signal-net routing and are limited by the quality of register placement. Existing publications also reflect this bias and focus mostly on clock routing. The few known techniques for register placement exhibit significant limitations and do not account for recent progress in large-scale placement and(More)
Angiotensinogen (AGT), the precursor of angiotensin I, is known to be involved in tumor angiogenesis and associated with the pathogenesis of coronary atherosclerosis. This study was undertaken to determine the role played by AGT in endothelial progenitor cells (EPCs) in tumor progression and metastasis. It was found that the number of EPC colonies formed by(More)
The generation of disease-specific induced pluripotent stem cell (iPSC) lines from patients with incurable diseases is a promising approach for studying disease mechanisms and drug screening. Such innovation enables to obtain autologous cell sources in regenerative medicine. Herein, we report the generation and characterization of iPSCs from fibroblasts of(More)