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Overexpression and molecular characterization of Aga50D from Saccharophagus degradans 2-40: an exo-type β-agarase producing neoagarobiose
Identification and analysis of the reaction product by mass spectrometry and 13C NMR showed that Aga50D had unique exo-lytic activity and was able to produce neoagarobiose directly from agarose. Expand
Natural inhibitors of carcinogenesis.
Based on this large pool of potential cancer chemopreventive compounds, structure-activity relationships are discussed in terms of the quinone reductase induction ability of flavonoids and withanolides and the cyclooxygenase-1 and -2 inhibitory activities of flavanones, flavones and stilbenoids. Expand
Cytotoxic and antineoplastic activity of timosaponin A-III for human colon cancer cells.
Treatment with compound 1 for four weeks significantly suppressed tumor growth in athymic nude mice bearing HCT-15 cells, without any overt toxicity. Expand
Ursolic acid is a PPAR-α agonist that regulates hepatic lipid metabolism.
It is confirmed that ursolic acid, a plant triterpenoid, activates peroxisome proliferator-activated receptor (PPAR)-α in vitro, and it is not a direct ligand of PPAR-α. Expand
Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo.
Bioassay-guided fractionation of the chloroform-soluble extract of the leaves of Vitex negundo led to the isolation of the known flavone vitexicarpin (1), which exhibited broad cytotoxicity in aExpand
Synergistic Antimicrobial Activity of Metabolites Produced by a Nonobligate Bacterial Predator
Both maculosin and banegasine were found to potentiate the antimicrobial activity of pyrrolnitrin, which appears to represent a new genus and species of eubacteria, Aristabacter necator, due to synergism between metabolites. Expand
Protuboxepins A and B and protubonines A and B from the marine-derived fungus Aspergillus sp. SF-5044.
Two new oxepin-containing (1 and 2) and two diketopiperazine-type alkaloids (3 and 4) have been isolated from an EtOAc extract of the marine-derived fungus Aspergillus sp. SF-5044. The structures ofExpand
Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages.
Two new isoflavanones (1 and 13), along with 25 known compounds (2-12, 14-27), were isolated from the EtOAc-soluble fraction of the heartwood of Dalbergia odorifera by following their potential toExpand
Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cells.
A bioassay-guided phytochemical investigation on the methanol extract of Boehmeria pannosa, using a HIF-1-mediated reporter gene assay, led to the isolation of two phenanthroquinolizidine alkaloids,Expand
Protection of prenylated flavonoids from mori cortex radicis (Moraceae) against nitric oxide-induced cell death in neuroblastoma SH-SY5Y cells
It is suggested that some prenylated flavonoids from Mori Cortex Radicis might protect neuronal cells against nitrosative stress-mediated cell death in neurodegenerative diseases. Expand