Overexpression and molecular characterization of Aga50D from Saccharophagus degradans 2-40: an exo-type β-agarase producing neoagarobiose
Identification and analysis of the reaction product by mass spectrometry and 13C NMR showed that Aga50D had unique exo-lytic activity and was able to produce neoagarobiose directly from agarose.
Blockade of Nuclear Factor-κB Signaling Pathway and Anti-Inflammatory Activity of Cardamomin, a Chalcone Analog from Alpinia conchigera
- Jeong-Hyung Lee, Haeng-Sun Jung, Jung Joon Lee
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 January 2006
Cardamomin is demonstrated to be valuable candidate for the intervention of NF-κB-dependent pathological condition such as inflammation and rescued C57BL/6 mice from LPS-induced mortality in conjunction with decreased serum level of TNF-α.
Cytotoxic and antineoplastic activity of timosaponin A-III for human colon cancer cells.
Treatment with compound 1 for four weeks significantly suppressed tumor growth in athymic nude mice bearing HCT-15 cells, without any overt toxicity.
Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo.
Bioassay-guided fractionation of the chloroform-soluble extract of the leaves of Vitex negundo led to the isolation of the known flavone vitexicarpin (1), which exhibited broad cytotoxicity in a…
Natural inhibitors of carcinogenesis.
Based on this large pool of potential cancer chemopreventive compounds, structure-activity relationships are discussed in terms of the quinone reductase induction ability of flavonoids and withanolides and the cyclooxygenase-1 and -2 inhibitory activities of flavanones, flavones and stilbenoids.
Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation.
Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages.
Lignans from Arctium lappa and their inhibition of LPS-induced nitric oxide production.
A new butyrolactone sesquilignan, isolappaol C (1) was determined by spectral analysis including 1D- and 2D-NMR, and strongly inhibited NO production in the LPS-stimulated RAW264.7 cells.
Synergistic Antimicrobial Activity of Metabolites Produced by a Nonobligate Bacterial Predator
Both maculosin and banegasine were found to potentiate the antimicrobial activity of pyrrolnitrin, which appears to represent a new genus and species of eubacteria, Aristabacter necator, due to synergism between metabolites.
Protuboxepins A and B and protubonines A and B from the marine-derived fungus Aspergillus sp. SF-5044.
- Sang Un Lee, Yukihiro Asami, Dongho Lee, Jae-Hyuk Jang, J. Ahn, H. Oh
- ChemistryJournal of Natural Products
- 2 March 2011
Two new oxepin-containing (1 and 2) and two diketopiperazine-type alkaloids (3 and 4) have been isolated from an EtOAc extract of the marine-derived fungus Aspergillus sp. SF-5044. The structures of…