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In the present study, the complete mitochondrial genome of the oval flounder Bothus myriaster was determined and a novel gene rearrangement was discovered. A striking finding was that eight genes encoded by the L-strand (ND6 and tRNA-Q, A, C, Y, S1, E, and P genes) were translocated to a position between tRNA-T and tRNA-F. Simultaneously, the original order(More)
BACKGROUND We have previously shown that palmitoylation is essential for NRAS leukemogenesis, suggesting that targeting RAS palmitoylation may be an effective therapy for NRAS-related cancers. For KRAS-driven cancer, although much research has been focused on the KRAS4B splice variant, which does not undergo palmitoylation, KRAS4A has recently been shown to(More)
Cynoglossus zanzibarensis (Cynoglossidae, Soleoidei) is characterized by both eyes on the left side of the body. Here we report the mitogenome of this tonguesole for the first time, which is 16,569 bp in length, with gene order reorganized. The tRNA-Gln gene is translocated from the light strand (L-strand) to the heavy strand (H-strand), accompanied by(More)
BACKGROUND Cancer stem cells are a subpopulation of malignant cells that have the capacity of both self-renewal and reconstitution of the cancer. Eradication of cancer stem cells is crucial for curing the malignant disease. Previous studies in hematopoietic malignancies showed that leukemia stem cells (LSCs) in chronic myelogenous leukemia (CML) chronic(More)
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