Amy Tsurumi2
Kimberly Larson2
Shian-Jang Yan2
Kriti Gaur1
Thomas H. Eickbush1
2Amy Tsurumi
2Kimberly Larson
2Shian-Jang Yan
1Kriti Gaur
1Thomas H. Eickbush
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  • Kimberly Larson, Shian-Jang Yan, Amy Tsurumi, Jacqueline Liu, Jun Zhou, Kriti Gaur +3 others
  • 2012
Organismal aging is influenced by a multitude of intrinsic and extrinsic factors, and heterochromatin loss has been proposed to be one of the causes of aging. However, the role of heterochromatin in animal aging has been controversial. Here we show that heterochromatin formation prolongs lifespan and controls ribosomal RNA synthesis in Drosophila. Animals(More)
The proto-oncoprotein Raf is pivotal for mitogen-activated protein kinase (MAPK) signaling, and its aberrant activation has been implicated in multiple human cancers. However, the precise molecular mechanism of Raf activation, especially for B-Raf, remains unresolved. By genetic and biochemical studies, we demonstrate that phosphorylation of tyrosine 510 is(More)
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