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OBJECTIVES To conduct a pilot study of weight-supported ambulation training after incomplete spinal cord injury (SCI), and to assess its safety. DESIGN Quasiexperimental, repeated measures, single group. SETTING Veterans Affairs medical center. PATIENTS Three subjects with incomplete, chronic, thoracic SCIs; 2 classified as D on the American Spinal(More)
This study employed neurophysiological methods to relate the condition of the corticospinal system with the voluntary control of lower-limb muscles in persons with motor-incomplete spinal cord injury. It consisted of two phases. In a group of ten healthy subjects, single and paired transcranial magnetic stimulation (TMS) of the motor cortex was used to(More)
Although a number of studies have evaluated kinematic stability changes in subjects with low back pain (LBP), the combined sensitivity of normalized standing stability from the ground force and kinematic rotational angle of the body segment were not carefully examined for postural responses. The purpose of this study was to evaluate normalized standing(More)
STUDY DESIGN An experimental design comparing kinematic changes in the lumbar spine axis in subjects with and without low back pain (LBP) while standing on one leg with and without visual feedback. OBJECTIVE The purpose of this study was to evaluate the lumbar stability index, which includes relative holding time (RHT) and relative standstill time (RST),(More)
Individuals with incomplete spinal cord injuries (SCI) retain varying degrees of voluntary motor control. The complexity of the motor control system and the nature of the recording biophysics have inhibited efforts to develop objective measures of voluntary motor control. This paper proposes the definition and use of a voluntary response index (VRI)(More)
STUDY DESIGN Cross-sectional retrospective study of a neurophysiological method of voluntary motor control characterization. OBJECTIVES This study was undertaken to validate the surface electromyography (sEMG)-based voluntary response index (VRI) as an objective, quantitative, laboratory measure of spinal cord injury severity in terms of voluntary motor(More)
In this paper, a method for analyzing surface electromyographic (sEMG) data recorded from the lower-limb muscles of incomplete spinal-cord injured (iSCI) subjects is evaluated. sEMG was recorded bilaterally from quadriceps, adductor, hamstring, tibialis anterior, and triceps surae muscles during voluntary ankle dorsiflexion performed in the supine position(More)
Polarization of cells by extracellular fields is relevant to neural stimulation, cardiac pacing, cardiac defibrillation, and electroporation. The electric field generated by an extracellular electrode may be nonuniform, and highly nonuniform fields are produced by microelectrodes and near the edges of larger electrodes. We solved analytically for the(More)
BACKGROUND The pharmacokinetics and pharmacodynamics of an anesthetic drug may be influenced by gender. The purpose of this study was to compare effect-site half maximal effective concentrations (EC50) of propofol in male and female patients during i-gel insertion with dexmedetomidine 0.5 μg/kg without muscle relaxants. METHODS Forty patients, aged 20-46(More)
INTRODUCTION IL-10 is an immunoregulatory cytokine which may modulate disease expression in rheumatoid arthritis (RA). The IL-10 gene is highly polymorphic with a number of single nucleotide polymorphisms in the promoter region and two microsatellite loci, IL10.R and IL10.G, 4 kb and 1.1 kb 5' of the transcription initiation site. It has been reported that(More)