Dong-Ye Wang

Learn More
AMP-activated protein kinase (AMPK) is a central cellular energy sensor and regulator of energy homeostasis, and a promising drug target for the treatment of diabetes, obesity, and cancer. Here we present low-resolution crystal structures of the human α1β2γ1 holo-AMPK complex bound to its allosteric modulators AMP and the glycogen-mimic cyclodextrin, both(More)
RATIONALE AND OBJECTIVES Cervical disc degeneration can result in nerve root compression and severe symptoms that significantly impair the patient's quality of life. The purpose of this study is to investigate multiple diffusion metrics changes in the diffusion tensor imaging (DTI) of cervical nerve roots and their relationship with the clinical severity of(More)
BMS309403 is a biphenyl azole inhibitor against fatty acid binding protein 4 (FABP4) and regarded as a lead compound for effective treatment of obesity related cardio-metabolic diseases. Here we discovered an off-target activity of BMS309403 in that it stimulates glucose uptake in C2C12 myotubes in a temporal and dose dependent manner via activation of(More)
Areas of Specialization struCtural Biology & BioinformatiCs Plant genetiCs Protein BioChemistry DeveloPmental Biology ComPutational BioinformatiCs laBoratory moleCular genetiCs of leaf DeveloPment PlastiD moleCular genetiCs moleCular genetiCs of meiotiC reComBination & Chromosome segregation moleCular Biology of Plant DeveloPment DeveloPmental & moleCular(More)
  • 1