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Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers.

• Vivian Wai Yan Lui, Matthew L. Hedberg, +26 authors Jennifer R Grandis
• Cancer discovery
• 2013

Genomic findings underscore the heterogeneity of head and neck squamous cell carcinoma (HNSCC). Identification of mutations that predict therapeutic response would be a major advance. We determined… (More)

Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species.

• Shivendra V Singh, Sanjay Kumar Srivastava, +10 authors Anna Herman-antosiewicz
• The Journal of biological chemistry
• 2005

We have shown previously that sulforaphane (SFN), a constituent of many edible cruciferous vegetables including broccoli, suppresses growth of prostate cancer cells in culture as well as in vivo by… (More)

Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo.

• Ajita Vikram Singh, Dong Xiao, Karen L. Lew, Rajiv Dhir, Shivendra V Singh
• Carcinogenesis
• 2004

Sulforaphane (SFN), a constituent of cruciferous vegetables, is highly effective in affording protection against chemically induced cancers in animal models. Here, we report that SFN inhibited… (More)

Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells.

• Ajay Bommareddy, E S Hahm, +4 authors Shivendra V Singh
• Cancer research
• 2009

Phenethyl isothiocyanate (PEITC) is a promising cancer chemopreventive agent but the mechanism of its anticancer effect is not fully understood. We now show, for the first time, that PEITC treatment… (More)

TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression.

• Umamaheswar Duvvuri, Daniel J Shiwarski, +13 authors Susanne M Gollin
• Cancer research
• 2012

Frequent gene amplification of the receptor-activated calcium-dependent chloride channel TMEM16A (TAOS2 or ANO1) has been reported in several malignancies. However, its involvement in human… (More)

Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells.

• Shivendra V Singh, Renaud Warin, +12 authors William H. Chambers
• Cancer research
• 2009

The present study shows that oral gavage of 6 mumol d,l-sulforaphane (SFN), a synthetic analogue of cruciferous vegetable-derived L isomer, thrice per week beginning at 6 weeks of age, significantly… (More)

Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis.

• Dong Xiao, Sanjay Kumar Srivastava, +5 authors Shivendra V Singh
• Carcinogenesis
• 2003

Dietary isothiocyanates (ITCs) are highly effective in affording protection against chemically induced cancers in laboratory animals. In the present study, we demonstrate that allyl isothiocyanate… (More)

Diallyl trisulfide-induced G2–M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc25C

• Dong Xiao, Anna Herman-antosiewicz, +4 authors Shivendra V Singh
• Oncogene
• 2005

Molecular mechanism of cell cycle arrest caused by diallyl trisulfide (DATS), a garlic-derived cancer chemopreventive agent, has been investigated using PC-3 and DU145 human prostate cancer cells as… (More)

Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential.

• Dong Xiao, Karen L. Lew, +4 authors Shivendra V Singh
• Carcinogenesis
• 2006

The present study was undertaken to gain insights into the molecular mechanism of apoptosis induction by phenethyl isothiocyanate (PEITC), which is a cancer chemopreventive constituent of cruciferous… (More)

Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2

• Dong Xiao, Sunga Choi, +5 authors Shivendra V Singh
• Oncogene
• 2004

Garlic-derived organosulfides (OSCs) including diallyl trisulfide (DATS) are highly effective in affording protection against chemically induced cancer in animals. Evidence is also mounting to… (More)

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