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RN486, a Selective Bruton's Tyrosine Kinase Inhibitor, Abrogates Immune Hypersensitivity Responses and Arthritis in Rodents
- Daigen Xu, Yong Kim, +17 authors J. Fine
- Chemistry, Medicine
- Journal of Pharmacology and Experimental…
- 1 April 2012
Genetic mutation and pharmacological inhibition of Bruton's tyrosine kinase (Btk) both have been shown to prevent the development of collagen-induced arthritis (CIA) in mice, providing a rationale… Expand
Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: implications for SYK…
IntroductionSpleen tyrosine kinase (SYK) is a key integrator of intracellular signals triggered by activated immunoreceptors, including Bcell receptors (BCR) and Fc receptors, which are important for… Expand
1745: Cystometric Studies with ATP, PPADS and TNP-ATP in Conscious and Anesthetized C57BL/6 Mice
3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models.
- M. Soth, J. Hermann, +36 authors Minh Diem Vu
- Chemistry, Medicine
- Journal of medicinal chemistry
- 10 January 2013
The Janus kinases (JAKs) are involved in multiple signaling networks relevant to inflammatory diseases, and inhibition of one or more members of this class may modulate disease activity or… Expand
Selective pharmacological blockade of the TRPV1 receptor suppresses sensory reflexes of the rodent bladder.
- Joseph S. Cefalu, Marlene A. Guillon, +6 authors D. Cockayne
- The Journal of urology
- 1 August 2009
PURPOSE We investigated the pharmacological effect of TRPV1 antagonists in anesthetized rodent models of bladder function. MATERIALS AND METHODS The TRPV1 antagonists JNJ17203212 and JYL1421 were… Expand
1740: Pharmacological Evaluation of IP Antagonists on Citric ACID-Induced Bladder Hyperreflexia in Conscious Rats and Mice
164: Are Gabab Receptors Involved in Gabapentin Inhibition of Micturition Hyperreflexia in Rodent Models?