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BACKGROUND AND PURPOSE Essential tremor (ET) is suggested to be a neural degenerative disease. The authors investigated the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) value in basal ganglia, thalamus, red nucleus, and substantia nigra in ET patients using diffusion tensor image (DTI). METHODS DTI examination was carried out in(More)
This protocol provides an introduction to soft lithography--a collection of techniques based on printing, molding and embossing with an elastomeric stamp. Soft lithography provides access to three-dimensional and curved structures, tolerates a wide variety of materials, generates well-defined and controllable surface chemistries, and is generally compatible(More)
PURPOSE Our previous study showed that apelin was increased in the vitreous and fibrotic membranes of patients with proliferative diabetic retinopathy (PDR) in vivo, which suggested that apelin may be involved in the development of PDR. In this study, we investigated whether the expression of apelin was upregulated in human retinal pigment epithelial (RPE)(More)
Achieving mastery over the synthesis of metal nanocrystals has emerged as one of the foremost scientific endeavors in recent years. This intense interest stems from the fact that the composition, size, and shape of nanocrystals not only define their overall physicochemical properties but also determine their effectiveness in technologically important(More)
Surface-enhanced Raman scattering (SERS) is a near-field phenomenon that relies on the intensified electric fields (Efields) on a metal nanostructure when its localized surface plasmon resonance (LSPR) is excited by light. Although it has been demonstrated that the hot spots between two or multiple Ag nanoparticles can amplify Raman signals by as much as 10(More)
Surface-enhanced Raman scattering (SERS) on gold nanohole and nanodisk arrays with precisely controlled size and spacing fabricated via electron beam lithography was investigated. These nanostructures exhibit strong SERS signals at 785 nm excitation but not at 514 nm. When the edge-to-edge distance is maintained, enhancement increases for nanoholes but(More)
We report a route to the facile synthesis of Ag@Pd-Ag nanocubes by cotitrating Na2PdCl4 and AgNO3 into an aqueous suspension of Ag nanocubes at room temperature in the presence of ascorbic acid and poly(vinylpyrrolidone). With an increase in the total titration volume, we observed the codeposition of Pd and Ag atoms onto the edges, corners, and side faces(More)
This chapter describes the methods and specific procedures used to fabricate microstructures by soft lithography. These techniques are useful for the prototyping of devices useful for applications in biotechnology. Fabrication by soft lithography does not require specialized or expensive equipment; the materials and facilities necessary are found commonly(More)
Thispaperdescribes severalmethods that generatepatterned relief structures for casting the elastomeric stamps required in microcontact printing (μCP). The relief structures include the following: (1) patterns etched in thin films of silver (200 nm thick) with printed SAMs of hexadecanethiolate as resists; (2) patterned polymeric structures assembled on the(More)