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Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy
Significance Cardiac hypertrophy and dysfunction in response to sustained hormonal and mechanical stress are sentinel features of most forms of heart disease. Activation of non–voltage-gatedExpand
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Hyperactive Adverse Mechanical Stress Responses in Dystrophic Heart Are Coupled to Transient Receptor Potential Canonical 6 and Blocked by cGMP–Protein Kinase G Modulation
Rationale: The heart is exquisitely sensitive to mechanical stimuli to adapt rapidly to physiological demands. In muscle lacking dystrophin, such as Duchenne muscular dystrophy, increased load duringExpand
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Thrombospondin-4 Is Required for Stretch-Mediated Contractility Augmentation in Cardiac Muscle
Rationale: One of the physiological mechanisms by which the heart adapts to a rise in blood pressure is by augmenting myocyte stretch-mediated intracellular calcium, with a subsequent increase inExpand
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Pathological Cardiac Hypertrophy Alters Intracellular Targeting of Phosphodiesterase Type 5 From Nitric Oxide Synthase-3 to Natriuretic Peptide Signaling
Background In the normal heart, phosphodiesterase type 5 (PDE5) hydrolyzes cGMP coupled to nitric oxide– (specifically from nitric oxide synthase 3) but not natriuretic peptide (NP)–stimulatedExpand
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Oxidation of 17alpha-ethinylestradiol with Mn(III) and product identification.
With increasing concern about the contamination of aquatic environments by estrogenic pollutants, removal of synthetic estrogens such as 17alpha-ethinylestradiol (EE2) has been widely studied,Expand
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Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors
Cardiac progenitor cells (CPCs) must control their number and fate to sustain the rapid heart growth during development, yet the intrinsic factors and environment governing these processes remainExpand
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Gold nanoparticles-based colorimetric assay for cathepsin B activity and the efficiency of its inhibitors.
Cathepsin B has been suggested to be a prognostic marker of melanoma, glioma, and a variety of cancers such as brain, breast, colon, esophageal, gastric, lung, ovarian, and thyroid cancers. CathepsinExpand
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New strategy for selective and sensitive assay of cathepsin B using a dityrosine-based material.
The increasing number of reports for disease-related proteases has necessitated materials for the fast, sensitive, and specific assessment of protease activities. The purpose of this study was toExpand
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Hierarchical Fault-Tolerant Control using Model Predictive Control for Wind Turbine Pitch Actuator Faults
Wind energy is one of the fastest growing energy sources in the world. It is expected that by the end of 2022 the installed capacity will exceed 250 GW thanks to the supply of large scale windExpand
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