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Lipase was covalently bound onto Fe(3)O(4) magnetic nanoparticles (12.7 nm) via carbodiimide activation. The Fe(3)O(4) magnetic nanoparticles were prepared by coprecipitating Fe(2+) and Fe(3+) ions in an ammonia solution and treating under hydrothermal conditions. The analyses of transmission electron microscopy (TEM) and X-ray diffraction (XRD) showed that(More)
Methotrexate (MTX), a stoichiometric inhibitor of dihydrofolate reductase, is a chemotherapeutic agent for treating a variety of neoplasms. Impairment of drug import into cells and increase in drug export from cells may render cells resistant to MTX. MTX, when locally administered in a soluble form, is rapidly absorbed through capillaries into the(More)
LaB6 nanoparticles possess excellent near-infrared (NIR) photothermal conversion properties. Vancomycin can interact strongly with a broad range of Gram-positive and Gram-negative bacteria. Fe3O4 nanoparticles could be used as the carrier for magnetic separation. In this work, vancomycin and Fe3O4 nanoparticles were successfully bound onto the surface of(More)
A novel magnetic nano-adsorbent was prepared by covalently binding polyacrylic acid (PAA) on Fe3O4 superparamagnetic nanoparticles (13.2 nm) via carbodiimide activation. The maximum weight ratio of PAA to Fe3O4 was 0.12 (i.e., average of two PAA molecules on a magnetic nanoparticle). The magnetic nano-adsorbent possessed a high ionic exchange capacity of(More)
Nanoparticles with an iron core and gold shell (denoted "Fe@AuÓ") have been reported to limit cancer-cell proliferation and therefore have been proposed as a potential anti-cancer agent. However, the underlying mechanisms are still unknown. In this study, we used flow cytometry, confocal fluorescence microscopy, and transmission electron microscopy to(More)
UNLABELLED Gold-coated iron nanoparticles (NPs) selectively and significantly (P <0.0001) inhibit proliferation of oral- and colorectal-cancer cells in vitro at doses as low as 5 μg/mL, but have little adverse effect on normal healthy control cells. The particle treatment caused delay in cell-cycle progression, especially in the S-phase. There was no(More)
OBJECTIVE Angiogenesis plays a part in the pathogenesis of rheumatoid arthritis (RA), and nanogold inhibits the activity of an angiogenic factor, vascular endothelial growth factor (VEGF). We therefore investigated whether intraarticular delivery of nanogold ameliorates collagen-induced arthritis (CIA) in rats. METHODS Binding of 13-nm nanogold to VEGF in(More)
This study presents near-infrared (NIR) light-responsive polymer-nanostructure composite microneedles used for on-demand transdermal drug delivery. Silica-coated lanthanum hexaboride (LaB6@SiO2) nanostructures were incorporated into polycaprolactone microneedles, serving as an NIR absorber. When the microneedles were irradiated with NIR light, light-to-heat(More)
We established near-infrared (NIR)-light-triggered transdermal delivery systems by encapsulating NIR absorbers, silica-coated lanthanum hexaboride (LaB6@SiO2) nanostructures and the cargo molecule to be released in biodegradable polycaprolactone (PCL) microneedles. Acting as a local heat source when exposed to an NIR laser, these nanostructures cause a(More)
Silver/iron oxide composite nanoparticles have been synthesized successfully via a facile one-pot green route by the use of l-arginine, which created an aqueous solution of about pH 10 and acted as a reducing agent for the successive formation of iron oxide and Ag nanoparticles. The product was characterized to be silver-coated iron oxide and iron oxide(More)