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Recognizing human action in non-instrumented video is a challenging task not only because of the variability produced by general scene factors like illumination, background, occlusion or intra-class variability, but also because of subtle behavioral patterns among interacting people or between people and objects in images. To improve recognition, a system(More)
BACKGROUND Oxidative stress is known to play an important role in the pathology of traumatic brain injury. Mitochondria are thought to be the major source of the damaging reactive oxygen species (ROS) following TBI. However, recent work has revealed that the membrane, via the enzyme NADPH oxidase can also generate the superoxide radical (O(2)(-)), and(More)
The overall biological role and clinical significance of long non-coding RNA H19 in colorectal cancer (CRC) remain largely unknown. Here, we firstly report that the lncRNA H19 recruits eIF4A3 and promotes the CRC cell proliferation. We observed higher expression of H19 was significantly correlated with tumor differentiation and advanced TNM stage in a(More)
JNK pathway is an important pro-apoptotic kinase cascade mediating cell death in response to a variety of extracellular stimuli including excitotoxicity, which results in selective and delayed neuronal death in the hippocampal CA1. On the contrary, activation of the protein kinase Akt, which is controlled by the opposing actions of PI3K and PTEN,(More)
—In order to realize the Smart Grid vision, it is necessary to have guaranteed Quality of Service (QoS) for the communication and networking technology used in various stages of the Smart Grid, ranging from power generation, transmission, distribution, to the customer applications. The low cost wireless protocols such as Zigbee (using IEEE 802.15.4 defined(More)
—Accurate estimation of PHY conditions would allow for better cross-layer resource management and provisioning. Unfortunately, Commercial-of-the-Shelf (COTS) typically provide very limited information. We utilize measurement studies to decipher LQI readings available in Zigbee radios with CC2420 chipset. Then, we verify the relationship between LQI readings(More)
BACKGROUND Recent work by our laboratory and others has implicated NADPH oxidase as having an important role in reactive oxygen species (ROS) generation and neuronal damage following cerebral ischemia, although the mechanisms controlling NADPH oxidase in the brain remain poorly understood. The purpose of the current study was to examine the regulatory and(More)
The blockade of aberrant hedgehog (Hh) signaling has shown promise for therapeutic intervention in cancer. A cell-based phenotypic high-throughput screen was performed, and the lead structure (1) was identified as an inhibitor of the Hh pathway via antagonism of the Smoothened receptor (Smo). Structure-activity relationship studies led to the discovery of a(More)
UNLABELLED Identification of pharmacological and toxicological profiles is of critical importance for the use of nanoparticles as drug carriers in nanomedicine and for the biosafety evaluation of environmental nanoparticles in nanotoxicology. Here we show that lysosomes are the pharmacological target organelles for single-walled carbon nanotubes (SWCNTs)(More)
Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated protein genes (cas genes) have been suggested to act as an immune system in archaea and bacteria mimicking the eukaryotic RNA interference (RNAi) system. We have investigated the properties of the protein SSO2001 from Sulfolobus solfataricus (Sso) P2, which is part of(More)